Evidence map›Paper›PMID 36046939›Full record

Trial reportObesity (Silver Spring, Md.)2022

Results of a 2-year lifestyle intervention for type 2 diabetes: the Reach Ahead for Lifestyle and Health-Diabetes randomized controlled trial.

Deborah J Wexler, Yuchiao Chang, Douglas E Levy, Bianca Porneala, Jeanna McCarthy, Anthony Rodriguez Romero, Valerie Goldman, Paul M Copeland, Jeanne Steppel-Reznik, Linda M Delahanty

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Obesity (Silver Spring, Md.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Deborah J WexlerDiabetes Center, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-6979-402X
Yuchiao ChangHarvard Medical School, Boston, Massachusetts, USA.
Douglas E LevyHarvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0001-9446-7899
Bianca PornealaDivision of General Internal Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Jeanna McCarthyDiabetes Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Anthony Rodriguez RomeroBoston Health Care for the Homeless Program (BHCHP), Boston, Massachusetts, USA.
Valerie GoldmanDiabetes Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Paul M CopelandHarvard Medical School, Boston, Massachusetts, USA.
Jeanne Steppel-ReznikDiabetes Center, Massachusetts General Hospital, Boston, Massachusetts, USA.
Linda M DelahantyDiabetes Center, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0002-1525-3559
Harvard University · USMassachusetts General Hospital · USBoston Health Care for the Homeless Program · USNewton Wellesley Hospital · US

Funding

New York Regional Center for Diabetes Translation Research - Translational Intervention Methodology CoreP30DK111022 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JEFFREY GONZALEZ · 2016 to 2026
$7.8M
REAL HEALTH-Diabetes: REach Ahead for Lifestyle and Health-DiabetesR18DK102737 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DELAHANTY, LINDA MICHELE, WEXLER, DEBORAH J · 2014 to 2018
$3.2M
NIDDK NIH HHS P30 DK111022NIDDK NIH HHS R18 DK102737
6 · The paper itself

Abstract

objectiveThe Reach Ahead for Lifestyle and Health (REAL HEALTH)-Diabetes study assessed the comparative effectiveness of two Look AHEAD (Action for Health in Diabetes)-adapted lifestyle intervention (LI) arms targeting weight loss in type 2 diabetes compared with medical nutrition therapy (MNT) referral. At 1 year, LI had greater weight loss than MNT. This study reports outcomes at 24 (end of LI) and 36 months.

methodsParticipants (N = 211) with type 2 diabetes and BMI > 25 kg/m

resultsParticipants were 61.7 (SD 10.2) years old; 55% were female; 77% were non-Hispanic White; and had mean (SD) weight of 98 (18.9) kg and mean (SD) HbA1c of 7.7% (1.2%). Mean (SD) weight change at 24 and 36 months was -4.4% (5.9%) and -4.4% (5.4%) in in-person LI, -4.0% (5.8%) and -5.3% (6.4%) in telephone LI, and -3.1% (5.2%) and -5.8% (7.1%) in MNT, with no statistically significant difference in weight or HbA1c at 24 and 36 months. Compared with MNT, LI arms had favorable changes in patient-reported outcomes related to learned dietary skills.

conclusionsThere were no differences in weight outcomes among LI participants compared with referral to MNT at the end of intervention or 1 year after its conclusion.

Indexed as

Diabetes Mellitus, Type 2AgedFemaleGlycated HemoglobinHumansLife StyleMaleMiddle AgedWeight LossGlycated Hemoglobin

Identifiers

PMID36046939
PMCPMC10949180
OpenAlexW4294123207

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.