Evidence map›Paper›PMID 36046792›Full record

ArticleFrontiers in endocrinology2022

Cell non-autonomous effect of hepatic growth differentiation factor 15 on the thyroid gland.

Seonhyang Jeong, Seul Gi Lee, Kook Hwan Kim, Xuguang Zhu, Woo Kyung Lee, Hwa Young Lee, Sunmi Park, Myung-Shik Lee, Sheue-Yann Cheng, Jandee Lee and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Seonhyang JeongDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Seul Gi LeeDepartment of Surgery, Daejeon Eulji Medical Center, Eulji University, Daejeon, South Korea.
Kook Hwan KimSeverance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, South Korea.
Xuguang ZhuLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Woo Kyung LeeLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Hwa Young LeeDepartment of Surgery, Open Nanotechnology Biotechnology Information technology Convergence Technology Research Laboratory, Severance Hospital, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.
Sunmi ParkDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Myung-Shik LeeDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Sheue-Yann ChengLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States.
Jandee LeeDepartment of Surgery, Open Nanotechnology Biotechnology Information technology Convergence Technology Research Laboratory, Severance Hospital, Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, South Korea.
Young Suk JoDepartment of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.
Yonsei University · KRNational Cancer Institute · USEulji University · KRNational Institutes of Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The thyroid gland plays an essential role in the regulation of body energy expenditure to maintain metabolic homeostasis. However, to date, there are no studies investigating the morphological and functional changes of the thyroid gland due to mitochondrial stress in metabolic organs such as the liver. We used data from the Genotype-Tissue Expression portal to investigate RNA expression patterns of the thyroid gland according to the expression of growth differentiation factor 15 (GDF15) such as the muscles and liver. To verify the effect of hepatic GDF15 on the thyroid gland, we compared the morphological findings of the thyroid gland from liver-specific GDF15 transgenic mice to that of wild type mice. High GDF15 expression in the muscles and liver was associated with the upregulation of genes related to hypoxia, inflammation (TGF-α

Indexed as

Growth Differentiation Factor 15Thyroid GlandAnimalsHumansLiverMiceMice, TransgenicThyrotropinGrowth Differentiation Factor 15ThyrotropinGDF15mitochondriamitochondrial stressmitokinethyroid cancer

Identifiers

PMID36046792
PMCPMC9420875
OpenAlexW4291383228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.