Evidence map›Paper›PMID 36046518›Full record

ArticleAmerican journal of ophthalmology case reports2022

Acute macular neuroretinopathy associated with intravitreal anti-VEGF injection: A case report.

Loubna M Radwan, Ghazi O Bou Ghanem, Ghassan N Daye, Nicola G Ghazi

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of ophthalmology case reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Systemic and ocular complications related to intravitreal administration of anti-VEGF agents.Medical hypothesis, discovery & innovation ophthalmology journal · 2026
    Review
  2. Atypical presentation of acute macular neuroretinopathy: a case description.Quantitative imaging in medicine and surgery · 2025
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Loubna M RadwanLAU Gilbert and Rose-Marie Chagoury School of Medicine, LAUMC/RH, Beirut, Lebanon, LAU Medical Center-Rizk Hospital, P.O. Box 11-3288, Beirut, Lebanon.
Ghazi O Bou GhanemLAU Gilbert and Rose-Marie Chagoury School of Medicine, LAUMC/RH, Beirut, Lebanon, LAU Medical Center-Rizk Hospital, P.O. Box 11-3288, Beirut, Lebanon.
Ghassan N DayeLAU Gilbert and Rose-Marie Chagoury School of Medicine, LAUMC/RH, Beirut, Lebanon, LAU Medical Center-Rizk Hospital, P.O. Box 11-3288, Beirut, Lebanon.
Nicola G GhaziLAU Gilbert and Rose-Marie Chagoury School of Medicine, LAUMC/RH, Beirut, Lebanon, LAU Medical Center-Rizk Hospital, P.O. Box 11-3288, Beirut, Lebanon.
University Medical Center Rizk Hospital · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: to report a case of acute macular neuroretinopathy occurring after intravitreal aflibercept injection for macular edema due to CRVO. Observations: Two days after Aflibercept intravitreal injection, the patient developed vision loss associated with a central scotoma. Optical coherence tomography showed a hyperreflective band at the level of the outer nuclear/outer plexiform layer corresponding to the patient's scotoma, ruling in the diagnosis of acute macular neuroretinopahty. Even though the OCT abnormalities resolved spontaneously, only partial resolution of the scotoma was observed 4 months later. Conclusions and importance: Acute macular neuroretinopathy might be associated with intravitreal anti-VEGF injection.

Indexed as

Acute macular neuroretinopahtyAfliberceptAnti-vascular endothelial growth factorOptical coherence tomography

Identifiers

PMID36046518
PMCPMC9421172
OpenAlexW4292241701

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.