ArticlePeerJ2022
Morphology of inner cell mass: a better predictive biomarker of blastocyst viability.
Article in PeerJ, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Misdiagnosis of different types of aneuploidy in preimplantation genetic testing (PGT): a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2026Pooled it
- Morphological parameters of the blastocyst to predict embryo quality: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2025Pooled it
- Beyond euploidy: the synergistic value of blastocyst morphology in predicting ongoing implantation in advanced maternal age women.Reproduction & fertility · 2026Article
- Applications of artificial intelligence in bovine reproductive assessment: focus on oocytes and blastocysts.Journal of assisted reproduction and genetics · 2026Review
- Inner Cell Mass Grade and Earlier Blastulation Are Associated with Pregnancy Outcomes in Euploid Embryos.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Oral exposure to di(2-ethylhexyl) phthalate alters the expression of GATA6, OCT4, and CDX2 in blastocysts and decreases the rate of implantation in a mouse model.Toxicological sciences : an official journal of the Society of Toxicology · 2025Article
- Embryo selection at the cleavage stage using Raman spectroscopy of day 3 culture medium and machine learning: a preliminary study.Frontiers in endocrinology · 2025Article
- Trophectoderm, Inner Cell Mass, and Expansion Status for Live Birth Prediction After Frozen Blastocyst Transfer: The Winner Is Trophectoderm.Life (Basel, Switzerland) · 2024Article
- Visual interpretability of image-based classification models by generative latent space disentanglement applied to in vitro fertilization.Nature communications · 2024Article
- Does cleavage stage morphology increase the discriminatory power of prediction in blastocyst transfer outcome?Journal of assisted reproduction and genetics · 2024Article
- THC and sperm: Impact on fertilization capability, pre-implantation in vitro development and epigenetic modifications.PloS one · 2024Article
- Novel embryo selection strategies-finding the right balance.Frontiers in reproductive health · 2023Article
- Advancing bovineFrontiers in bioengineering and biotechnology · 2023Article
- Beyond the Inner Cell Mass: Evaluating the Impact of Inner Cell Mass Visibility on Implantation Prediction in Static Blastocyst Images - A Retrospective Cohort Study.Journal of human reproductive sciencesArticle
- Beyond the Inner Cell Mass: Evaluating the Impact of Inner Cell Mass Visibility on Implantation Prediction in Static Blastocyst Images.Journal of human reproductive sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Transfer of embryos at the blastocyst stage is one of the best approaches for achieving a higher success rate in Methods: This prospective study included women undergoing single or double frozen blastocyst transfers following their autologous cycles in a period between October 2020 and September 2021. The morphological grades (A-good, B-average, and C-poor) of inner cell mass (ICM) and trophectoderm (TE) of blastocysts with known implantation were compared to assess their predictive potential of pregnancy outcome. It was further explored by measuring the relationship between the two variables using logistic regression and receiver operating characteristic (ROC) analysis. Results: A total of 1,972 women underwent frozen embryo transfer (FET) cycles with a total of 3,786 blastocysts. Known implantation data (KID) from 2,060 blastocysts of 1,153 patients were subjected to statistical analysis, the rest were excluded. Implantation rates (IR) from transfer of ICM/TE grades AA, AB, BA, BB were observed as 48.5%, 39.4%, 23.4% and 25% respectively. There was a significantly higher IR observed in blastocysts with ICM grade A ( Conclusion: This study confirms that the morphology of ICM of the blastocyst is a stronger predictor of implantation and clinical pregnancy than that of TE and can be utilized as a biomarker of viability.
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Registered trials
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