Evidence map›Paper›PMID 36046500›Full record

ArticlePatient preference and adherence2022

Medication Adherence Evaluated Through Electronic Monitors During the 2020 COVID-19 Pandemic Lockdown in Switzerland: A Longitudinal Analysis.

Carole Bandiera, Jérôme Pasquier, Isabella Locatelli, Anne Niquille, Grégoire Wuerzner, Jennifer Dotta-Celio, Anna Hachfeld, Gilles Wandeler, Anna Dorothea Wagner, Chantal Csajka and 3 more

Open access · goldAbstract read
In one paragraph

Article in Patient preference and adherence, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. The differential impact of a 6-Frontiers in pharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Carole BandieraSchool of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-9996-3100
Jérôme PasquierCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-5554-2988
Isabella LocatelliCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-0870-1461
Anne NiquilleInstitute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, University of Lausanne, Geneva, Switzerland.ORCID 0000-0001-8643-5731
Grégoire WuerznerService of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-6424-7630
Jennifer Dotta-CelioCenter for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-8500-817X
Anna HachfeldDepartment of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0001-9308-7130
Gilles WandelerDepartment of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.ORCID 0000-0002-5278-8763
Anna Dorothea WagnerService of Oncology, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-4728-7013
Chantal CsajkaSchool of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-0660-082X
Anne ZanchiService of Nephrology and Hypertension, Department of Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-0987-9333
Matthias CavassiniService of Infectious Diseases, Department of Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-0933-7833
Marie P SchneiderSchool of Pharmaceutical Sciences, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-7557-9278
University of Geneva · CHUniversity of Lausanne · CHCentre universitaire de médecine générale et santé publique, Lausanne · CHUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: During the 2020 COVID-19 lockdown, patients included in the Interprofessional Medication Adherence Program (IMAP) in Switzerland continued to use electronic monitors (EMs) that registered daily drug-dose intake. We aimed to understand to what extent patients' medication implementation (ie, the extent to which the patient took the prescribed medicine), measured with EMs, was impacted by the lockdown. Methods: Patients participating in the IMAP were diagnosed with diabetic kidney disease (DKD), solid cancer, human immunodeficiency virus (HIV) and miscellaneous long-term diseases (MLTD). Patient implementation was defined through a proxy: if all patient EMs were opened at least once daily, implementation was considered active (=1), and no implementation was considered (=0) otherwise. Implementation before (from December 2019 to March 2020), during (March to June 2020) and after (June to September 2020) the lockdown was compared. Subanalyses were performed according to the patients' diseases. Subanalyses were performed in patients who used at least one EM in 2018-2019 during the same periods (defined as winter, spring and summer). The logistic regression models used to estimate medication implementation according to the period were fitted using generalized estimating equations. Results: In 2020, patient implementation (n = 118) did not differ significantly before versus during (OR = 0.98, 95% CI: 0.84-1.15, p = 0.789) and before versus after (OR = 0.91, 95% CI: 0.79-1.06, p = 0.217) the lockdown. These findings remained stable when separately analyzing the implementation of patients with HIV (n = 61), DKD (n = 25) or MLTD (n = 22). Too few patients with cancer were included (n = 10) to interpret the results. In 2019, the implementation of 61/118 (51.7%) patients was significantly lower during summertime versus wintertime (OR = 0.73, 95% CI: 0.60-0.89, p = 0.002). Conclusion: Medication implementation remained steady before, during and after the lockdown in 2020. The IMAP before, during and after the lockdown may have supported the adherence of most patients, by ensuring continuity of care during periods of routine disturbances.

Indexed as

COVID-19electronic adherence monitoringimplementation adherenceinterprofessional adherence interventionmedication adherencepatient complianceSARS-CoV-2

Identifiers

PMID36046500
PMCPMC9423122
OpenAlexW4293203214

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.