Evidence map›Paper›PMID 36046385›Full record

ReviewExploration of targeted anti-tumor therapy2020

An overview of immune checkpoint inhibitors in breast cancer.

Federica Miglietta, Maria Silvia Cona, Maria Vittoria Dieci, Valentina Guarneri, Nicla La Verde

Open access · diamondAbstract readReview
In one paragraph

Review in Exploration of targeted anti-tumor therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Neoadjuvant radiotherapy in ERFrontiers in immunology · 2024
    Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Federica MigliettaDepartment of Surgery, Oncology and Gastroenterology, University of Padova, 35122 Padova, Italy.ORCID https://orcid.org/0000-0001-6203-874X
Maria Silvia ConaDepartment of Oncology, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, Via G.B. Grassi 74, 20157 Milano, Italy.ORCID https://orcid.org/0000-0002-1838-7819
Maria Vittoria DieciDepartment of Surgery, Oncology and Gastroenterology, University of Padova, 35122 Padova, Italy.ORCID https://orcid.org/0000-0002-3967-9861
Valentina GuarneriDepartment of Surgery, Oncology and Gastroenterology, University of Padova, 35122 Padova, Italy.ORCID https://orcid.org/0000-0002-2375-8397
Nicla La VerdeDepartment of Oncology, Luigi Sacco Hospital, ASST Fatebenefratelli Sacco, Via G.B. Grassi 74, 20157 Milano, Italy.ORCID https://orcid.org/0000-0002-2884-1632
Istituto Oncologico Veneto · ITLuigi Sacco Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although breast cancer is not traditionally considered an immunogenic type of tumor, the combination of immunotherapy and chemotherapy has recently emerged as a novel treatment option in triple-negative subtype in the advanced setting and other similar combinations of immune checkpoint inhibitors with chemotherapy are expected to become part of the neoadjuvant management in the near future. In addition, encouraging results have been observed with the combination of immune checkpoint blockade with diverse biological agents, including anti-HER2 agents, CDK 4/6 inhibitors, PARP-inhibitors. The present review summarized the available evidence coming from clinical trials on the role of immune checkpoint inhibitors in the management of breast cancer, both in advanced and early setting.

Indexed as

Early breast cancerimmune checkpoint inhibitorsimmunotherapymetastatic breast cancer

Identifiers

PMID36046385
PMCPMC9400749
OpenAlexW3114400551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.