Evidence map›Paper›PMID 36046194›Full record

ArticleiScience2022

Fetal sex-specific epigenetic associations with prenatal maternal depressive symptoms.

Michelle Z L Kee, Ai Ling Teh, Andrew Clappison, Irina Pokhvisneva, Julie L MacIssac, David T S Lin, Katia E Ramadori, Birit F P Broekman, Helen Chen, Mary Lourdes Daniel and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Biomarkers of stress resilience: A review.Neuroscience applied · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

Michelle Z L KeeTranslation Neuroscience, Singapore Institute for Clinical Sciences, ASTAR, Singapore 117609, Singapore.
Ai Ling TehBioinformatics, Singapore Institute for Clinical Sciences, ASTAR, Singapore 117609, Singapore.
Andrew ClappisonDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3, Canada.
Irina PokhvisnevaDepartment of Psychiatry, Douglas Mental Health University Institute, McGill University, Montreal, QC H4H 1R3, Canada.
Julie L MacIssacCentre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
David T S LinCentre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Katia E RamadoriCentre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Birit F P BroekmanTranslation Neuroscience, Singapore Institute for Clinical Sciences, ASTAR, Singapore 117609, Singapore.
Helen ChenDepartment of Psychological Medicine (Mental Wellness Service), KK Women's and Children's Hospital, Singapore 229899, Singapore.
Mary Lourdes DanielDepartment of Child Development, KK Women's and Children's Hospital, Singapore 229899, Singapore.
Neerja KarnaniTranslation Neuroscience, Singapore Institute for Clinical Sciences, ASTAR, Singapore 117609, Singapore.
Michael S KoborCentre for Molecular Medicine and Therapeutics, BC Children's Hospital Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, BC V5Z 4H4, Canada.
Peter D GluckmanTranslation Neuroscience, Singapore Institute for Clinical Sciences, ASTAR, Singapore 117609, Singapore.
Yap Seng ChongYong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Jonathan Y HuangTranslation Neuroscience, Singapore Institute for Clinical Sciences, ASTAR, Singapore 117609, Singapore.
Michael J MeaneyTranslation Neuroscience, Singapore Institute for Clinical Sciences, ASTAR, Singapore 117609, Singapore.
Agency for Science, Technology and Research · SGUniversity of British Columbia · CADouglas Mental Health University Institute · CAKK Women's and Children's Hospital · SGNational University of Singapore · SG

Funding

Medical Research Council G1001357Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_PC_19009Wellcome Trust
6 · The paper itself

Abstract

Prenatal maternal mental health is a global health challenge with poorly defined biological mechanisms. We used maternal blood samples collected during the second trimester from a Singaporean longitudinal birth cohort study to examine the association between inter-individual genome-wide DNA methylation and prenatal maternal depressive symptoms. We found that (1) the maternal methylome was significantly associated with prenatal maternal depressive symptoms

Indexed as

Biological sciencesDevelopmental biologyDevelopmental neuroscienceNeurogenetics

Identifiers

PMID36046194
PMCPMC9421382
OpenAlexW4289755411

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.