Evidence map›Paper›PMID 36046129›Full record

ArticleFrontiers in nutrition2022

Combined systemic inflammatory immunity index and prognostic nutritional index scores as a screening marker for sarcopenia in patients with locally advanced gastric cancer.

Ping'an Ding, Jingxia Lv, Chenyu Sun, Shuya Chen, Peigang Yang, Yuan Tian, Qin Zhou, Honghai Guo, Yang Liu, Qun Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 8 pooled it
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 8 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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  16. Predictive value of preoperative L3-SMI, AGR, and PNI for overall survival in patients undergoing radical gastrectomy for gastric cancer.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Ping'an DingThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Jingxia LvThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Chenyu SunAMITA Health Saint Joseph Hospital Chicago, Chicago, IL, United States.
Shuya ChenNewham University Hospital, London, United Kingdom.
Peigang YangThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Yuan TianThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Qin ZhouRadiation Oncology, Mayo Clinic, Rochester, MN, United States.
Honghai GuoThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Yang LiuThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Qun ZhaoThe Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Fourth Hospital of Hebei Medical University · CNHebei Medical University · CNMayo Clinic in Arizona · USNewham University Hospital · GBSaint Joseph Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sarcopenia is associated with poor clinical outcomes in patients with locally advanced gastric cancer (LAGC). Currently, the diagnostic criteria for sarcopenia are complex and laborious. Increased evidence suggests the inflammatory state of the body is closely associated with the development of sarcopenia. The systemic immune-inflammatory index (SII) and the prognostic nutritional index (PNI) are representative blood indicators of the status of the systemic inflammatory response, but the clinical significance of the combined testing of these two indicators remains unclear. We aimed to develop a simple and practical risk score (SII-PNI score) to screen patients with LAGC for sarcopenia on admission for early diagnosis. Methods: We registered a prospective clinical study from January 2011 to May 2016 involving 134 patients with LAGC undergoing radical surgical resection. All patients followed the definition of sarcopenia in the Asian Working Group on Sarcopenia (AWGS) guidelines and were divided into sarcopenia and non-sarcopenia groups. SII-PNI score 0-2 was scored as 2 for high SII (≥432.9) and low PNI ( ≤ 49.5); score 1, either high SII or low PNI; score 0, no high SII or low PNI. Results: All patients underwent radical surgery, including 31 patients (23.13%) with sarcopenia according to AWGS criteria. The SII-PNI score was significantly lower in the non-sarcopenic patients than in the sarcopenic patients ( Conclusion: Peripheral blood parameters SII-PNI scores accurately identify sarcopenia in patients with LAGC and could be used as potential systemic markers.

Indexed as

locally advanced gastric cancermarkerprognostic nutritional indexsarcopeniasystemic immune-inflammatory index

Identifiers

PMID36046129
PMCPMC9421237
OpenAlexW4291885730

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.