ReviewNature and science of sleep2022
Impact of Desaturation Patterns versus Apnea-Hypopnea Index in the Development of Cardiovascular Comorbidities in Obstructive Sleep Apnea Patients.
Review in Nature and science of sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Hypoxic Burden, Clinical Implication of a New Biomarker in the Cardiovascular Management of Sleep Apnea Patients: A Systematic Review.Reviews in cardiovascular medicine · 2024Pooled it
- Sleep homeostasis impairment across obstructive sleep apnea severity: findings from a population-based cohort study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Altered HIF-1α, Netrin-1, and Netrin-4 Levels in Obstructive Sleep Apnea: Associations with Intermittent Hypoxia and Disease Severity.Medicina (Kaunas, Lithuania) · 2026Article
- Nocturnal hypoxemic burden in obesity hypoventilation syndrome compared to obstructive sleep apnea: a case-control study.Sleep & breathing = Schlaf & Atmung · 2026Article
- Physiological phenotypes of obstructive sleep apnea identified by cluster analysis: Association with type 2 diabetes.Journal of diabetes investigation · 2026Article
- Differential cardiovascular and autonomic responses to structurally distinct intermittent hypoxia paradigms in rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Association of reduced REM sleep with mortality in adults with coronary artery disease and obstructive sleep apnea in the RICCADSA cohort.Sleep & breathing = Schlaf & Atmung · 2026Article
- Linking sleep apnea and arthritis in the National Alzheimer Coordinating Center Cohort: A cross-sectional analysis.Medicine · 2026Article
- Clinical phenotypes of obstructive sleep apnea identified using cluster analysis.Respiratory research & clinical practice · 2026Article
- REM-related obstructive sleep apnea: low AHI-high hypoxemia paradox.Sleep & breathing = Schlaf & Atmung · 2025Article
- Sleep-Disordered Breathing and Clinical Presentation in Infants with Congenital Laryngomalacia: A Polysomnographic Study.Journal of clinical medicine · 2025Article
- Maxillary Expansion in the Management of Obstructive Sleep Apnea: A Comprehensive Review.Dentistry journal · 2025Review
- Application of cardiopulmonary coupled sleep monitoring technology in sleep analysis of glaucoma patients.International ophthalmology · 2025Article
- [Residual hypoxemia during titration with self-adjusting CPAP at home in patients without prior adaptation]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2025Article
- Challenges in Obstructive Sleep Apnea Management in Elderly Patients.Journal of clinical medicine · 2024Review
- Correlation analysis of LXR and its target genes COX2 and CETP with the severity of OSAHS in obese young rats.Sleep & breathing = Schlaf & Atmung · 2024Article
- Drug therapies for obstructive sleep apnoea: a systematic review and meta-analysis protocol.BMJ open · 2024Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Various phenotypes of obstructive sleep apnea (OSA) have been recently described and are poorly assessed by the commonly used polysomnographic indices, such as the apnea-hypopnea index and oxygen desaturation index. Nocturnal hypoxemia is the hallmark of OSA and new quantitative markers, as hypoxic burden or desaturation severity, have been shown to be associated with cardiovascular (CV) mortality. The purpose of this overview is to review the endophenotypical and clinical characteristics of OSA, the current metrics, and to analyze different measurements of hypoxemia in OSA to predict the cardiovascular impact (eg hypoxic burden). Potential interest of multidimensional models to classify OSA, such as BAVENO classification, is also discussed, with the goal of focusing on specific endophenotypes that are likely to develop CV comorbidities, in order to guide clinicians to more aggressive management of OSA in these individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.