Evidence map›Paper›PMID 36045707›Full record

ArticleCurrent research in immunology2022

Dach1 transcription factor regulates the expression of peripheral node addressin and lymphocyte trafficking in lymph nodes.

Arisa Shintani, Shoko Fukai, Reika Nobusawa, Kanako Taniguchi, Tomohiro Hatatani, Hayato Nagai, Tomohiro Sakai, Takuji Yoshimura, Masayuki Miyasaka, Haruko Hayasaka

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Novel immunologic mechanisms for Fontan-associated liver disease.International journal of cardiology. Congenital heart disease · 2025
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Arisa ShintaniFaculty of Science & Engineering, Department of Science, Graduate School of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, Japan.
Shoko FukaiWPI Immunology Frontier Research Center, Osaka University, 2-2, Yamada-oka, Suita, Osaka, Japan.
Reika NobusawaFaculty of Science & Engineering, Department of Science, Graduate School of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, Japan.
Kanako TaniguchiWPI Immunology Frontier Research Center, Osaka University, 2-2, Yamada-oka, Suita, Osaka, Japan.
Tomohiro HatataniFaculty of Science & Engineering, Department of Science, Graduate School of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, Japan.
Hayato NagaiFaculty of Science & Engineering, Department of Science, Graduate School of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, Japan.
Tomohiro SakaiFaculty of Science & Engineering, Department of Science, Graduate School of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, Japan.
Takuji YoshimuraThe Department of Pediatrics, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, Japan.
Masayuki MiyasakaWPI Immunology Frontier Research Center, Osaka University, 2-2, Yamada-oka, Suita, Osaka, Japan.
Haruko HayasakaFaculty of Science & Engineering, Department of Science, Graduate School of Science and Engineering, Kindai University, 3-4-1, Kowakae, Higashiosaka, Osaka, Japan.
Kindai University · JPThe University of Osaka · JPNara Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphocytes regulate the immune response by circulating between the vascular and lymphatic systems. High endothelial venules, HEVs, special blood vessels expressing selective adhesion molecules, such as PNAd and MAdCAM-1, mediate naïve lymphocyte migration from the vasculature into the lymph nodes and Peyer's patches. We have identified that DACH1 is abundantly expressed in developing HEV-type endothelial cells. DACH1 showed a restricted expression pattern in lymph node blood vessels during the late fetal and early neonatal periods, corresponding to HEV development. The proportion of MAdCAM-1

Indexed as

ECs, endothelial cellsEndothelial cellHEV, High endothelial venulesILNs, Inguinal lymph nodesLNs, Lymph nodeLymph nodeLymphocytemAb, monoclonal antibodyMAdCAM-1, mucosal addressin cell adhesion molecule-1MLNs, Mesenteric lymph nodesPNAd, peripheral node addressinPPs, Peyer's patchesTraffickingTranscription factor

Identifiers

PMID36045707
PMCPMC9421177
OpenAlexW4292537094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.