ArticleInhalation toxicology2022
Analyses on the influence of normal nasal morphological variations on odorant transport to the olfactory cleft.
Article in Inhalation toxicology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 13 citations in OpenAlex.
- Impact of Intra-Phenotypic Nasal Vestibular Variation on Local Airflow Dynamics.The Laryngoscope · 2025Article
- Insights into exercise-induced rhinitis based on nasal aerodynamics induced by airway morphology.Respiratory physiology & neurobiology · 2024Article
- Characterizing Olfactory Dysfunction in Patients with Unilateral Cleft Lip Nasal Deformities.Facial plastic surgery & aesthetic medicineArticle
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveOlfaction requires a combination of sensorineural components and conductive components, but conductive mechanisms have not typically received much attention. This study investigates the role of normal nasal vestibule morphological variations in ten healthy subjects on odorant flux in the olfactory cleft. MATERIALS AND
methodsComputed tomography images were used to create subject-specific nasal models. Each subject's unilateral nasal cavity was classified according to its nasal vestibule shape as Standard or Notched. Inspiratory airflow simulations were performed at 15 L/min, simulating resting inspiration using computational fluid dynamics modeling. Odorant transport simulations for three odorants (limonene, 2,4-dinitrotoluene, and acetaldehyde) were then performed at concentrations of 200 ppm for limonene and acetaldehyde, and 0.2 ppm for dinitrotoluene. Olfactory cleft odorant flux was computed for each simulation. RESULTS AND DISCUSSION AND
conclusionSimulated results showed airflow in the olfactory cleft was greater in the Standard phenotype compared to the Notched phenotype. For Standard, median airflow was greatest in the anterior region (0.5006 L/min) and lowest in the posterior region (0.1009 L/min). Median airflow in Notched was greatest in the medial region (0.3267 L/min) and lowest in the posterior region (0.0756 L/min). Median olfactory odorant flux for acetaldehyde and limonene was greater in Standard (Acetaldehyde: Standard = 140.45 pg/cm
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