Evidence map›Paper›PMID 36045419›Full record

ArticleJournal of hematology & oncology2022

Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT).

Michal Grzmil, Paul Boersema, Ashish Sharma, Alain Blanc, Stefan Imobersteg, Martin Pruschy, Paola Picotti, Roger Schibli, Martin Behe

Open access · goldAbstract readLetter
In one paragraph

Article in Journal of hematology & oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Current Perspectives on Radiosensitizers in Cancer Radiotherapy.International journal of nanomedicine · 2026
    Review
  2. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Michal GrzmilCenter for Radiopharmaceutical Sciences, Paul Scherrer Institute, Villigen, Switzerland. michal.grzmil@psi.ch.
Paul BoersemaInstitute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland.
Ashish SharmaDepartment of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.
Alain BlancCenter for Radiopharmaceutical Sciences, Paul Scherrer Institute, Villigen, Switzerland.
Stefan ImoberstegCenter for Radiopharmaceutical Sciences, Paul Scherrer Institute, Villigen, Switzerland.
Martin PruschyDepartment of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland.
Paola PicottiInstitute of Molecular Systems Biology, Department of Biology, ETH Zurich, Zurich, Switzerland.
Roger SchibliCenter for Radiopharmaceutical Sciences, Paul Scherrer Institute, Villigen, Switzerland.
Martin BeheCenter for Radiopharmaceutical Sciences, Paul Scherrer Institute, Villigen, Switzerland.ORCID 0000-0002-1110-2665
Paul Scherrer Institute · CHETH Zurich · CHUniversity Hospital of Zurich · CH

Funding

Swiss Cancer Research Foundation KFS-3960-08-2016-R
6 · The paper itself

Abstract

The vast majority of our knowledge regarding cancer radiobiology and the activation of radioresistance mechanisms emerged from studies using external beam radiation therapy (EBRT). Yet, less is known about the cancer response to internal targeted radionuclide therapy (TRT). Our comparative phosphoproteomics analyzed cellular responses to TRT with lutetium-177-labeled minigastrin analogue [

Indexed as

NeoplasmsRadioisotopesAnimalsCell Line, TumorErbB ReceptorsIntegrinsMiceMice, NudeErbB ReceptorsIntegrinsRadioisotopesCCKBRErlotinibMinigastrinPhosphoproteomicsRadioresistance

Identifiers

PMID36045419
PMCPMC9429584
OpenAlexW4293773308

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.