Evidence map›Paper›PMID 36045319›Full record

ArticleBMC pregnancy and childbirth2022

Preconception mental health and the relationship between antenatal depression or anxiety and gestational diabetes mellitus: a population-based cohort study.

Grace A Thiele, Deirdre M Ryan, Tim F Oberlander, Gillian E Hanley

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07003503 (Explore the Risk Factors for Antenatal Mental Disorders in Pregnant Women With Hyperglycemia), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07003503 not yet recruitingnot on this mapstarted 2025, after this paper: background citation

Explore the Risk Factors for Antenatal Mental Disorders in Pregnant Women With Hyperglycemia

TypeobservationalSponsorShenzhen Hospital of Southern Medical UniversityRan2025 to 2026Enrolled635ConditionsHyperglycemia, Mental Disorder, Pregnancy Complications
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Grace A ThieleDepartment of Obstetrics & Gynaecology, University of British Columbia, Rm 590 828 West 10th Ave, Vancouver, BC, V5Z 1M9, Canada.
Deirdre M RyanDepartments of Psychiatry, University of British Columbia (UBC), 938 W 28th Ave, Vancouver, BC, V5Z 4H4, Canada.
Tim F OberlanderDepartment of Pediatrics, University of British Columbia (UBC), 938 W 28th Ave, Vancouver, Canada.
Gillian E HanleyDepartment of Obstetrics & Gynaecology, University of British Columbia, Rm 590 828 West 10th Ave, Vancouver, BC, V5Z 1M9, Canada. Gillian.hanley@vch.ca.
University of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntenatal depression and anxiety are highly prevalent conditions that have been associated with increased risk for myriad adverse outcomes. Current literature exploring the connection between antenatal mental health and gestational diabetes mellitus (GDM) is limited, presenting conflicting evidence. We sought to evaluate the association between antenatal depression/anxiety (DEP-ANX) and GDM using population-based, administrative data, accounting for aspects of preconception mental health.

methodsIn this population-based retrospective cohort study, we included all singleton births in British Columbia, Canada from April 1, 2000, to December 31, 2014. We identified instances of DEP-ANX from outpatient and inpatient records that included relevant diagnostic codes and stratified our cohort by preconception DEP-ANX persistence. Logistic regression models were run to estimate odds of GDM given antenatal DEP-ANX. Models were adjusted for the birthing person's socio-demographics and pregnancy characteristics. Using an expanded cohort, we ran conditional logistic regression models that matched birthing people to themselves (in a subsequent pregnancy) based on discordance of exposure and outcome.

resultsOut of the 228,144 births included in this study, 43,664 (19.1%) were to birthing people with antenatal health service use for DEP-ANX. There were 4,180 (9.6%) cases of GDM among those antenatal exposure to DEP-ANX compared to 15,102 (8.2%) among those without exposure (SMD 0.049). We observed an unadjusted odds ratio (OR) of 1.19 (95% CI: 1.15 - 1.23) and fully adjusted OR of 1.15 (95% CI: 1.11 - 1.19) overall. Apparent risk for GDM given antenatal DEP-ANX was highest among the no DEP-ANX history stratum, with a fully adjusted OR of 1.24 (95% CI: 1.15 - 1.34). Associations estimated by matched sibling analysis were non-significant (fully adjusted OR 1.19 [95% CI: 0.86 - 1.63]).

conclusionsResults from this population-based study suggest an association between antenatal DEP-ANX and GDM that varied based on mental health history. Our analysis could suggest that incident cases of DEP-ANX within pregnancy are more closely associated with GDM compared to recurring or chronic cases.

Indexed as

Diabetes, GestationalAnxietyBritish ColumbiaCohort StudiesDepressionFemaleHumansMental HealthPregnancyRetrospective StudiesAdministrative dataAnxietyDepressionGestational diabetes mellitusPerinatal mental healthRetrospective cohort study

Identifiers

PMID36045319
PMCPMC9429302
OpenAlexW4293764834

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.