ArticleNature2022
A microbial supply chain for production of the anti-cancer drug vinblastine.
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Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 193 papers.
0numbers the graph read from it
0cells of the map it votes in
193citing papers in PubMed
68.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
193 citing papers in PubMed, 421 citations in OpenAlex.
- Characterization of two key cytochrome P450 enzymes inSynthetic and systems biotechnology · 2027Article
- Engineering the paclitaxel biosynthetic pathway in Physcomitrium patens for de novo and stable biosynthesis.Nature communications · 2026Article
- Highly multiplexed mammalian metabolic engineering with a shotgun approach.Nature biotechnology · 2026Article
- AgBiSMaterials today. Bio · 2026Article
- Structural basis of mevalonate pathway regulation by feedback inhibition of mevalonate kinase.The Journal of biological chemistry · 2026Article
- Novel production of vinblastine by immobilized cultures of mutant strain of the endophytic Alternaria alternata.World journal of microbiology & biotechnology · 2026Article
- Systematic prioritization of candidate genes in camptothecin biosynthesis using multi-omics and deep learning.The plant genome · 2026Article
- Yeast species resource exploration and application in cell factories.Synthetic and systems biotechnology · 2026Review
- Advances in large DNA fragment assembly for microbial cell factory engineering.Quantitative biology (Beijing, China) · 2026Review
- Cell-Specific Expression and Cellular Compartmental Regulation in Camptothecin Biosynthesis.Plant biotechnology journal · 2026Article
- Metabolic and transport engineering enable efficient de novo biosynthesis of patchoulol inSynthetic and systems biotechnology · 2026Article
- A Comprehensive Review on the Biosynthesis of Tropane Alkaloids.Molecules (Basel, Switzerland) · 2026Review
- Article
- Nitrene generation and transfer for unnatural biosynthesis in living cells.Nature chemistry · 2026Article
- Divergent and precise alkaloid remodelling with a small suite of reactions.Nature chemistry · 2026Article
- Completing the acylation landscape in plants: GDSL enzymes join the BAHD and SCPL acyltransferase families.Journal of experimental botany · 2026Review
- Fine-tuned synthetic transcription factors for production of 3'-phosphoadenosine-5'-phosphosulfate in yeast.Microbial cell factories · 2026Article
- Co-Overexpression ofPlants (Basel, Switzerland) · 2026Article
- Cinchona alkaloid scaffold decoded.Plant communications · 2026Article
- Systems metabolic engineering of Corynebacterium glutamicum for efficient production of L-isoleucine.Journal of animal science and biotechnology · 2026Article
133 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 4 institutions in 5 countries.
Jie ZhangNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Lea G HansenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0002-8454-312X
Olga GudichNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Konrad ViehrigNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0003-0992-3904
Lærke M M LassenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Lars SchrübbersNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Khem B AdhikariNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Paulina RubaszkaNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Elena Carrasquer-AlvarezNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0001-9292-9631
Ling ChenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.ORCID http://orcid.org/0000-0001-6341-6191
Vasil D'AmbrosioNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Beata LehkaNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Ahmad K HaidarNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Saranya NallapareddyNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Konstantina GiannakouNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Marcos LalouxNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Dushica ArsovskaNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Marcus A K JørgensenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Leanne Jade G ChanJoint BioEnergy Institute, Emeryville, CA, USA.
Mette KristensenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Hanne B ChristensenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Suresh SudarsanNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Emily A StanderEA2106 Biomolecules and Plant Biotechnology, University of Tours, Tours, France.ORCID http://orcid.org/0000-0002-8382-0631
Edward BaidooJoint BioEnergy Institute, Emeryville, CA, USA.
Christopher J PetzoldJoint BioEnergy Institute, Emeryville, CA, USA.ORCID http://orcid.org/0000-0002-8270-5228
Tune WulffNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.
Sarah E O'ConnorDepartment of Natural Product Biosynthesis, Max Planck Institute for Chemical Ecology, Jena, Germany.ORCID http://orcid.org/0000-0003-0356-6213
Vincent CourdavaultEA2106 Biomolecules and Plant Biotechnology, University of Tours, Tours, France.ORCID http://orcid.org/0000-0001-8902-4532
Michael K JensenNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark. mije@biosustain.dtu.dk.ORCID http://orcid.org/0000-0001-7574-4707
Jay D KeaslingNovo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark. keasling@berkeley.edu.ORCID http://orcid.org/0000-0003-4170-6088
Novo Nordisk Foundation · DKLawrence Berkeley National Laboratory · USUniversité de Tours · FRMax Planck Institute for Chemical Ecology · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine
Indexed as
Antineoplastic AgentsBioreactorsBiosynthetic PathwaysMetabolic EngineeringSaccharomyces cerevisiaeVinblastineVinca AlkaloidsCatharanthusGenes, FungalGenes, PlantPolyisoprenyl PhosphatesTryptophanAntineoplastic Agentscatharanthinegeranyl pyrophosphatePolyisoprenyl PhosphatesTryptophanVinblastineVinca Alkaloids
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.