ArticleNature2022
African-specific molecular taxonomy of prostate cancer.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed, 1 pooled it
10.6field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 74 citations in OpenAlex.
- Meta-analysis reveals differences in somatic alterations by genetic ancestry across common cancers.Nature genetics · 2025Pooled it
- Single-cell and spatial RNA sequencing in prostate cancer.Nature reviews. Urology · 2026Review
- Men's Knowledge, Attitudes, Practices, Cultural Beliefs, and Perceived Risk and Susceptibility Regarding Prostate Cancer in the Vhembe District, Limpopo Province, South Africa.Journal of racial and ethnic health disparities · 2026Article
- Article
- Africa's emerging role in precision oncology: translational insights from the harnessing functional genomics in cancer research conference, Windhoek, 23-26 September 2025.BMC proceedings · 2026Article
- Epigenetic modulation of prostate cancer disparities in men with African ancestry.Nature reviews. Urology · 2026Review
- Single base focal hypermutation cooccurs with structural variation as an early event in advanced prostate tumourigenesis with ancestry specific independence: a multi-ancestral observational study.Genome medicine · 2026Observational
- A unique transcriptomic landscape defines African-specific grade group 1 prostate cancer.Research square · 2026Article
- Integrative molecular analyses of lineage identity and morphology in aggressive variant prostate cancer.NPJ precision oncology · 2026Article
- Immune gene diversity and STING1 variants in shaping cancer immunity across different genetic ancestry populations.Cell reports · 2026Article
- A catalogue of early diverged contemporary human genome variation reveals distinct Khoe-San populations.Nature communications · 2026Article
- Molecular decoupling of lineage identity and morphology in aggressive variant prostate cancer.medRxiv : the preprint server for health sciences · 2026Article
- Insights into human history and complex traits from the genomes of African populations.Molecular biology and evolution · 2026Review
- Article
- Knowledge about prostate cancer and screening among men attending Kibogora Level Two Teaching Hospital.Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2026Article
- Methylation reprogramming associated with aggressive prostate cancer and ancestral disparities.Molecular systems biology · 2025Article
- Single base focal hypermutation cooccurs with structural variation as an early event in advanced prostate tumourigenesis with ancestry specific independence: a multi-ancestral observational study.Research square · 2025Article
- Germline-Somatic Liaison Dictates Cancer Subtypes via de novo Steroid Biosynthesis.Cancer discovery · 2025Article
- Pathogenic variants reveal candidate genes for prostate cancer germline testing for men of African ancestry.Nature communications · 2025Article
- Scaling for African Inclusion in High-Throughput Whole Cancer Genome Bioinformatic Workflows.Cancers · 2025Review
Corrections and comments
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Authors and funding
21 authors at 10 institutions in 6 countries.
Weerachai JaratlerdsiriAncestry and Health Genomics Laboratory, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.ORCID http://orcid.org/0000-0001-9100-1807
Jue JiangAncestry and Health Genomics Laboratory, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.
Tingting GongAncestry and Health Genomics Laboratory, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.
Sean M PatrickSchool of Health Systems & Public Health, University of Pretoria, Pretoria, South Africa.
Cali WilletSydney Informatics Hub, University of Sydney, Darlington, New South Wales, Australia.
Tracy ChewSydney Informatics Hub, University of Sydney, Darlington, New South Wales, Australia.ORCID http://orcid.org/0000-0001-9529-7705
Ruth J LyonsGenomics and Epigenetic Theme, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
Anne-Maree HaynesGenomics and Epigenetic Theme, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
Gabriela PasqualimEndocrine and Tumor Molecular Biology Laboratory (LABIMET), Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Melanie LouwNational Health Laboratory Services, Johannesburg, South Africa.ORCID http://orcid.org/0000-0002-9827-1225
James G KenchDepartment of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital and Central Clinical School, University of Sydney, Sydney, New South Wales, Australia.
Raymond CampbellKalafong Academic Hospital, Pretoria, South Africa.
Lisa G HorvathGenomics and Epigenetic Theme, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.
Eva K F ChanGenomics and Epigenetic Theme, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.ORCID http://orcid.org/0000-0002-6104-3763
David C WedgeDivision of Cancer Sciences, University of Manchester, Manchester, UK.ORCID http://orcid.org/0000-0002-7572-3196
Rosemarie SadsadSydney Informatics Hub, University of Sydney, Darlington, New South Wales, Australia.
Ilma Simoni BrumEndocrine and Tumor Molecular Biology Laboratory (LABIMET), Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID http://orcid.org/0000-0002-7428-825X
Shingai B A MutambirwaDepartment of Urology, Sefako Makgatho Health Science University, Dr George Mukhari Academic Hospital, Medunsa, South Africa.
Phillip D StrickerGenomics and Epigenetic Theme, Garvan Institute of Medical Research, Darlinghurst, New South Wales, Australia.ORCID http://orcid.org/0000-0002-0934-0656
M S Riana BornmanSchool of Health Systems & Public Health, University of Pretoria, Pretoria, South Africa.ORCID http://orcid.org/0000-0003-3975-2333
Vanessa M HayesAncestry and Health Genomics Laboratory, Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia. vanessa.hayes@sydney.edu.au.ORCID http://orcid.org/0000-0002-4524-7280
The University of Sydney · AUGarvan Institute of Medical Research · AUUniversity of Pretoria · ZAKalafong Hospital · ZANational Health Laboratory Service · ZANew South Wales Department of Health · AUSefako Makgatho Health Sciences University · ZAUniversidade Federal do Rio Grande · BRUniversidade Federal do Rio Grande do Sul · BRUniversity of Manchester · GB
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prostate cancer is characterized by considerable geo-ethnic disparity. African ancestry is a significant risk factor, with mortality rates across sub-Saharan Africa of 2.7-fold higher than global averages
Indexed as
Black PeopleProstatic NeoplasmsAfricaAfrica South of the SaharaAsian PeopleCarrier ProteinsChinaEthnicityEuropeHumansMaleMutationNuclear ProteinsNuclear Receptor Coactivator 2Protein Serine-Threonine KinasesRNA HelicasesCarrier ProteinsDHX16 protein, humanlong non-coding RNA PCAT1, humanNCOA2 protein, humanNuclear ProteinsNuclear Receptor Coactivator 2Protein Serine-Threonine KinasesRNA HelicasesRNA, Long NoncodingSETBP1 protein, humanSTK19 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.