Evidence map›Paper›PMID 36045288›Full record

ArticleNature2022

The role of somatosensory innervation of adipose tissues.

Yu Wang, Verina H Leung, Yunxiao Zhang, Victoria S Nudell, Meaghan Loud, M Rocio Servin-Vences, Dong Yang, Kristina Wang, Maria Dolores Moya-Garzon, Veronica L Li and 3 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed, 1 pooled it
11.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 1 synthesis or guideline pooled it, 100 citations in OpenAlex.

  1. [Recent Advances in the Interorgan Regulatory Roles of Adipose Tissue].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Peripheral Neuropathy in Metabolic Stress.International journal of molecular sciences · 2026
    Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Advances in Adipose Tissue Biology.Endocrine reviews · 2026
    Review
  20. The DMHAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Yu WangDepartment of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA.ORCID http://orcid.org/0000-0002-1327-5789
Verina H LeungDepartment of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA.
Yunxiao ZhangDepartment of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA.ORCID http://orcid.org/0000-0003-2145-4151
Victoria S NudellDepartment of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA.
Meaghan LoudDepartment of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA.
M Rocio Servin-VencesDepartment of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA.
Dong YangDepartment of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA.ORCID http://orcid.org/0000-0003-0612-1439
Kristina WangDepartment of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA.
Maria Dolores Moya-GarzonDepartment of Pathology, Stanford School of Medicine, Sarafan ChEM-H, Stanford University, Stanford, CA, USA.
Veronica L LiDepartment of Pathology, Stanford School of Medicine, Sarafan ChEM-H, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-8888-3853
Jonathan Z LongDepartment of Pathology, Stanford School of Medicine, Sarafan ChEM-H, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2631-7463
Ardem PatapoutianDepartment of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA. ardem@scripps.edu.ORCID http://orcid.org/0000-0003-0726-7034
Li YeDepartment of Neuroscience, Dorris Neuroscience Center, Scripps Research, San Diego, CA, USA. liye@scripps.edu.ORCID http://orcid.org/0000-0002-3077-802X
Scripps Health · USStanford University · USScripps Research Institute · US

Funding

Mechanisms of force sensing in the nervous systemR35NS105067 · NINDS · SCRIPPS RESEARCH INSTITUTE, THE · PI PATAPOUTIAN, ARDEM · 2018 to 2025
$6.1M
The Role of Sensory Neurons Innervating Internal OrgansR01AT012051 · NCCIH · SCRIPPS RESEARCH INSTITUTE, THE · PI PATAPOUTIAN, ARDEM · 2022 to 2025
$2.9M
Modulating somatosensory network to target metabolic diseasesDP2DK128800 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI YE, LI · 2020 to 2020
$2.7M
Brain-wide functional mapping of circuits controlling hedonic feeding in obesityK01DK114165 · NIDDK · STANFORD UNIVERSITY · PI YE, LI · 2017 to 2021
$825k
Feeding regulation by cortical-amygdala circuitsR03DK124731 · NIDDK · SCRIPPS RESEARCH INSTITUTE, THE · PI YE, LI · 2020 to 2021
$266k
Howard Hughes Medical InstituteNCCIH NIH HHS R01 AT012051NIDDK NIH HHS DP2 DK128800NIDDK NIH HHS K01 DK114165NIDDK NIH HHS R03 DK124731NINDS NIH HHS R35 NS105067
6 · The paper itself

Abstract

Adipose tissues communicate with the central nervous system to maintain whole-body energy homeostasis. The mainstream view is that circulating hormones secreted by the fat convey the metabolic state to the brain, which integrates peripheral information and regulates adipocyte function through noradrenergic sympathetic output

Indexed as

Adipose TissueSensory Receptor CellsAdipose Tissue, BeigeAnimalsAxonsEnergy MetabolismGanglia, SpinalHomeostasisHormonesMiceOrgan SpecificitySubcutaneous FatSympathetic Nervous SystemThermogenesisHormones

Identifiers

PMID36045288
PMCPMC9477745
OpenAlexW4293793095

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.