Evidence map›Paper›PMID 36045017›Full record

ArticleJournal of medical imaging and radiation sciences2022

Computational dose visualization & comparison in total skin electron treatment suggests superior coverage by the rotational versus the Stanford technique.

Tianshun Miao, Rongxiao Zhang, Michael Jermyn, Petr Bruza, Timothy Zhu, Brian W Pogue, David J Gladstone, Benjamin B Williams

Abstract read
In one paragraph

Article in Journal of medical imaging and radiation sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tianshun MiaoThayer School of Engineering, Dartmouth College, Hanover NH, 03755, USA.
Rongxiao ZhangThayer School of Engineering, Dartmouth College, Hanover NH, 03755, USA; Department of Medicine, Radiation Oncology, Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, NH 03766, USA.
Michael JermynThayer School of Engineering, Dartmouth College, Hanover NH, 03755, USA; DoseOptics, LLC, Lebanon NH 03755 USA.
Petr BruzaThayer School of Engineering, Dartmouth College, Hanover NH, 03755, USA; DoseOptics, LLC, Lebanon NH 03755 USA.
Timothy ZhuDepartment of Radiation Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia PA, 19104 USA.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover NH, 03755, USA; DoseOptics, LLC, Lebanon NH 03755 USA; Department of Medical Physics, University of Wisconsin-Madison, Wisconsin WI 53705 USA. Electronic address: bpogue@wisc.edu.
David J GladstoneThayer School of Engineering, Dartmouth College, Hanover NH, 03755, USA; Department of Medicine, Radiation Oncology, Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, NH 03766, USA.
Benjamin B WilliamsThayer School of Engineering, Dartmouth College, Hanover NH, 03755, USA; Department of Medicine, Radiation Oncology, Norris Cotton Cancer Center, Dartmouth Hitchcock Medical Center, Lebanon, NH 03766, USA.

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
OPTICAL CHERENKOV IMAGING DOSIMETRY IN HUMAN RADIOTHERAPYR01EB023909 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI GLADSTONE, DAVID J., JARVIS, LESLEY A · 2017 to 2024
$4.4M
Cherenkov imaging of Total Skin Electron Therapy (TSET)R21CA239127 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ZHU, TIMOTHY C. · 2020 to 2021
$386k
NCI NIH HHS P30 CA023108NCI NIH HHS R21 CA239127NIBIB NIH HHS R01 EB023909
6 · The paper itself

Abstract

INTRODUCTION/

backgroundThe goal of Total Skin Electron Therapy (TSET) is to achieve a uniform surface dose, although assessment of this is never really done and typically limited points are sampled. A computational treatment simulation approach was developed to estimate dose distributions over the body surface, to compare uniformity of (i) the 6 pose Stanford technique and (ii) the rotational technique.

methodsThe relative angular dose distributions from electron beam irradiation was calculated by Monte Carlo simulation for cylinders with a range of diameters, approximating body part curvatures. These were used to project dose onto a 3D body model of the TSET patient's skin surfaces. Computer animation methods were used to accumulate the dose values, for display and analysis of the homogeneity of coverage.

resultsThe rotational technique provided more uniform coverage than the Stanford technique. Anomalies of under dose were observed in lateral abdominal regions, above the shoulders and in the perineum. The Stanford technique had larger areas of low dose laterally. In the rotational technique, 90% of the patient's skin was within ±10% of the prescribed dose, while this percentage decreased to 60% or 85% for the Stanford technique, varying with patient body mass. Interestingly, the highest discrepancy was most apparent in high body mass patients, which can be attributed to the loss of tangent dose at low angles of curvature. DISCUSSION/

conclusionThis simulation and visualization approach is a practical means to analyze TSET dose, requiring only optical surface body topography scans. Under- and over-exposed body regions can be found, and irradiation could be customized to each patient. Dose Area Histogram (DAH) distribution analysis showed the rotational technique to have better uniformity, with most areas within 10% of the umbilicus value. Future use of this approach to analyze dose coverage is possible as a routine planning tool.

Indexed as

ElectronsSkin NeoplasmsHumansMonte Carlo MethodRadiotherapy DosageSkinAnimationComputer graphicsElectron therapyMonte CarloVisualization

Identifiers

PMID36045017
PMCPMC10152509

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.