Evidence map›Paper›PMID 36044903›Full record

ArticleCurrent biology : CB2022

Genomes from a medieval mass burial show Ashkenazi-associated hereditary diseases pre-date the 12th century.

Selina Brace, Yoan Diekmann, Thomas Booth, Ruairidh Macleod, Adrian Timpson, Will Stephen, Giles Emery, Sophie Cabot, Mark G Thomas, Ian Barnes

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Selina BraceDepartment of Earth Sciences, The Natural History Museum, Cromwell Road, London SW7 5BD, UK.
Yoan DiekmannResearch Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK; Palaeogenetics Group, Institute of Organismic and Molecular Evolution (iomE), Johannes Gutenberg-University Mainz, 55099 Mainz, Germany.
Thomas BoothDepartment of Earth Sciences, The Natural History Museum, Cromwell Road, London SW7 5BD, UK; Francis Crick Institute, London NW1 1AT, UK; UCL Genetics Institute, University College London, London, UK.
Ruairidh MacleodDepartment of Earth Sciences, The Natural History Museum, Cromwell Road, London SW7 5BD, UK; Research Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK; Department of Archaeology, University of Cambridge, Downing Street, Cambridge CB2 3DZ, UK.
Adrian TimpsonResearch Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK.
Will StephenDepartment of Earth Sciences, The Natural History Museum, Cromwell Road, London SW7 5BD, UK.
Giles EmeryNorvic Archaeology, 7 Foxburrow Road, Norwich NR7 8QU, UK.
Sophie CabotNorfolk Record Office, The Archive Centre, Martineau Lane, Norwich, Norfolk NR1 2DQ, UK.
Mark G ThomasResearch Department of Genetics, Evolution and Environment, University College London, Gower Street, London WC1E 6BT, UK. Electronic address: m.thomas@ucl.ac.uk.
Ian BarnesDepartment of Earth Sciences, The Natural History Museum, Cromwell Road, London SW7 5BD, UK. Electronic address: i.barnes@nhm.ac.uk.
Natural History Museum · GBUniversity College London · GBJohannes Gutenberg University Mainz · DENorfolk Record Office · GB

Funding

Wellcome TrustWellcome Trust 100713/Z/12/Z
6 · The paper itself

Abstract

We report genome sequence data from six individuals excavated from the base of a medieval well at a site in Norwich, UK. A revised radiocarbon analysis of the assemblage is consistent with these individuals being part of a historically attested episode of antisemitic violence on 6 February 1190 CE. We find that four of these individuals were closely related and all six have strong genetic affinities with modern Ashkenazi Jews. We identify four alleles associated with genetic disease in Ashkenazi Jewish populations and infer variation in pigmentation traits, including the presence of red hair. Simulations indicate that Ashkenazi-associated genetic disease alleles were already at appreciable frequencies, centuries earlier than previously hypothesized. These findings provide new insights into a significant historical crime, into Ashkenazi population history, and into the origins of genetic diseases associated with modern Jewish populations.

Indexed as

BurialJewsAllelesGene FrequencyHumansancient DNAAshkenaziBritaingenetic diseaseJewishMedieval

Identifiers

PMID36044903
PMCPMC10499757
OpenAlexW4293692933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.