Evidence map›Paper›PMID 36044899›Full record

ArticleImmunity2022

Innate type 2 immunity controls hair follicle commensalism by Demodex mites.

Roberto R Ricardo-Gonzalez, Maya E Kotas, Claire E O'Leary, Katelyn Singh, William Damsky, Chang Liao, Elizabeth Arouge, Iliana Tenvooren, Diana M Marquez, Andrew W Schroeder and 12 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. First Detection of Human- and Dog-AssociatedPathogens (Basel, Switzerland) · 2026
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  15. Reducing ocularFrontiers in allergy · 2025
    Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 4 institutions in 1 country.

Roberto R Ricardo-GonzalezDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA; Department of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA. Electronic address: roberto.ricardo-gonzalez@ucsf.edu.
Maya E KotasDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Claire E O'LearyDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Katelyn SinghDepartment of Dermatology, Yale School of Medicine, New Haven, CT, USA.
William DamskyDepartment of Dermatology, Yale School of Medicine, New Haven, CT, USA; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.
Chang LiaoDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Elizabeth ArougeDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.
Iliana TenvoorenDepartment of Otolaryngology and Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA.
Diana M MarquezDepartment of Otolaryngology and Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA.
Andrew W SchroederDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jarish N CohenDepartment of Pathology, University of California, San Francisco, San Francisco, CA, USA.
Marlys S FassettDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA; Department of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA.
Jinwoo LeeDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Scott G DanielDivision of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Kyle BittingerDivision of Gastroenterology, Hepatology, and Nutrition, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Roberto Efraín DíazDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA; Tetrad Graduate Program, University of California, San Francisco, San Francisco, CA, USA.
James S FraserDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Niwa AliDepartment of Dermatology, University of California, San Francisco, San Francisco, CA, USA.
K Mark AnselDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA.
Matthew H SpitzerDepartment of Otolaryngology and Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA; Parker Institute for Cancer Immunotherapy, San Francisco, CA, USA; Chan Zuckerberg Biohub, San Francisco, CA, USA.
Hong-Erh LiangDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Richard M LocksleyDepartment of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA; Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA, USA. Electronic address: richard.locksley@ucsf.edu.
University of California, San Francisco · USChildren's Hospital of Philadelphia · USYale University · USChan Zuckerberg Initiative (United States) · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Role of miRNAs in Th2-Driven inflammation in AsthmaP01HL107202 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FAHY, JOHN V · 2012 to 2023
$23.3M
UCSF Dermatology Training GrantT32AR007175 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Wilson Liao, Michael David Rosenblum · 1986 to 2026
$6.1M
Short-Term Reserch Training: Students in Health SchoolsT35HL007649 · NHLBI · YALE UNIVERSITY · PI Sarwat I Chaudhry, Erica L Herzog · 1987 to 2026
$5.7M
Parasite immunity orchestrated by type 2 immune cellsR01AI026918 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 1988 to 2022
$3.8M
Parasite Immunity Orchestrated by Th2 CellsR37AI026918 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOCKSLEY, RICHARD M · 2006 to 2015
$3.8M
Elucidating the role of type 2 immunity in skin homeostasisK08AR075880 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI RICARDO-GONZALEZ, ROBERTO RAFAEL · 2019 to 2023
$888k
Interleukin-31 at the neuroimmune interface of pruritus and dermatitisK08AR074556 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FASSETT, MARLYS S · 2019 to 2023
$887k
Delineation of the immunobiology of sarcoidosis and characterization of the effects of Janus kinase inhibitionK08AI159229 · NIAID · YALE UNIVERSITY · PI DAMSKY, WILLIAM · 2021 to 2025
$861k
Role of ILC2s in lung maintenance and repairF32HL140868 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KOTAS, MAYA · 2018 to 2020
$168k
Development and Function of Biliary Tuft CellsF32DK121476 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI O'LEARY, CLAIRE E · 2020 to 2022
$144k
NCATS NIH HHS UL1 TR001863NCIRD CDC HHS H23 IP000554NHLBI NIH HHS F32 HL140868NHLBI NIH HHS P01 HL107202NHLBI NIH HHS T35 HL007649NIAID NIH HHS K08 AI159229NIAID NIH HHS R01 AI026918NIAID NIH HHS R37 AI026918NIAMS NIH HHS K08 AR074556NIAMS NIH HHS K08 AR075880NIAMS NIH HHS T32 AR007175NIDDK NIH HHS F32 DK121476
6 · The paper itself

Abstract

Demodex mites are commensal parasites of hair follicles (HFs). Normally asymptomatic, inflammatory outgrowth of mites can accompany malnutrition, immune dysfunction, and aging, but mechanisms restricting Demodex outgrowth are not defined. Here, we show that control of mite HF colonization in mice required group 2 innate lymphoid cells (ILC2s), interleukin-13 (IL-13), and its receptor, IL-4Ra-IL-13Ra1. HF-associated ILC2s elaborated IL-13 that attenuated HFs and epithelial proliferation at anagen onset; in their absence, Demodex colonization led to increased epithelial proliferation and replacement of gene programs for repair by aberrant inflammation, leading to the loss of barrier function and HF exhaustion. Humans with rhinophymatous acne rosacea, an inflammatory condition associated with Demodex, had increased HF inflammation with decreased type 2 cytokines, consistent with the inverse relationship seen in mice. Our studies uncover a key role for skin ILC2s and IL-13, which comprise an immune checkpoint that sustains cutaneous integrity and restricts pathologic infestation by colonizing HF mites.

Indexed as

Mite InfestationsMitesAnimalsCytokinesHair FollicleHumansImmunity, InnateInflammationInterleukin-13LymphocytesMiceSymbiosisCytokinesInterleukin-13barrier functionDemodex miteshair follicle stem cellIL-13ILC2innate immunityrhinophymaskin homeostasistissue immunitytype 2 immunity

Identifiers

PMID36044899
PMCPMC9561030
OpenAlexW4293574382

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.