ArticleScience advances2022
JAG1-NOTCH4 mechanosensing drives atherosclerosis.
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Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26citing papers in PubMed
3.6field-weighted citation impact, top 5% of its field
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26 citing papers in PubMed, 36 citations in OpenAlex.
- Polycomb Repressive Complex 2 drives flow-sensitive endothelial states underlying vascular inflammation and disease.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- PCYT2 inhibits lipid accumulation via the notch signaling pathway in chicken primary hepatocytes.Poultry science · 2026Article
- Review
- A noncanonical role for Jagged1 in endothelial mechanotransduction.The FEBS journal · 2026Article
- Article
- Research progress on targeted regulatory proteins in the prevention and treatment of atherosclerosis.Frontiers in immunology · 2026Review
- Mechanosensitive interactions between Jag1 and Myo1c control Jag1 trafficking in endothelial cells.iScience · 2025Article
- Endothelial-to-Mesenchymal Transition in Health and Disease: Molecular Insights and Therapeutic Implications.International journal of molecular sciences · 2025Review
- Rewiring the luteal microenvironment: hemodynamic and molecular insights into eCG-supported CL development in indigenous White Lamphun cattle.Reproduction & fertility · 2025Article
- Targeting miR-337 mitigates disuse-induced bone loss.Cell discovery · 2025Article
- Endothelial c-REL orchestrates atherosclerosis at regions of disturbed flow through crosstalk with TXNIP-p38 and non-canonical NF-κB pathways.Cardiovascular research · 2025Article
- In the flow, how fluid dynamics shapes amyloid formation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multifaceted Role of Notch Signaling in Vascular Health and Diseases.Biomedicines · 2025Review
- The cellular and molecular cardiac tissue responses in human inflammatory cardiomyopathies after SARS-CoV-2 infection and COVID-19 vaccination.Nature cardiovascular research · 2025Article
- Atherosclerosis: A Comprehensive Review of Molecular Factors and Mechanisms.International journal of molecular sciences · 2025Review
- Emerging therapy targets to modulate microbiome-mediated effects evident in cardiovascular disease.Frontiers in cardiovascular medicine · 2025Review
- Advanced Imaging Techniques for Atherosclerosis and Cardiovascular Calcification in Animal Models.Journal of cardiovascular development and disease · 2024Review
- Single-cell spatial transcriptomics in cardiovascular development, disease, and medicine.Genes & diseases · 2024Review
- EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites Through Endothelial Fatty Acid Uptake.Circulation research · 2024Article
- Regulation of YAP Promotor Accessibility in Endothelial Mechanotransduction.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
Corrections and comments
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Authors and funding
24 authors at 9 institutions in 6 countries.
Celine SouilholDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.ORCID 0000-0002-3410-353X
Blanca Tardajos AyllonDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.ORCID 0000-0001-6466-8366
Xiuying LiSchool of Pharmacy, Southwest Medical University, LuZhou, Sichuan 646000, P.R. China.
Mannekomba R DiagbougaDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.ORCID 0000-0002-2641-5445
Ziqi ZhouDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.ORCID 0000-0001-6401-2797
Lindsay CanhamDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.ORCID 0000-0003-3005-8855
Hannah RoddieDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.
Daniela PirriDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.ORCID 0000-0002-7051-4176
Emily V ChambersSheffield Bioinformatics Core, Sheffield Institute of Translational Neuroscience, University of Sheffield, Sheffield, UK.ORCID 0000-0003-1252-8059
Mark J DunningSheffield Bioinformatics Core, Sheffield Institute of Translational Neuroscience, University of Sheffield, Sheffield, UK.ORCID 0000-0002-8853-9435
Mark AriaansDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.ORCID 0000-0002-7392-8278
Jin LiBiological Sciences Division, Department of Medicine, University of Chicago, Chicago, IL, USA.
Yun FangBiological Sciences Division, Department of Medicine, University of Chicago, Chicago, IL, USA.ORCID 0000-0003-4597-3095
Helle F JørgensenDivision of Cardiovascular Medicine, University of Cambridge, Addenbrooke's Centre for Clinical Investigation, Addenbrooke's Hospital, Cambridge, UK.ORCID 0000-0002-7909-2977
Michael SimonsDepartment of Internal Medicine, Yale Cardiovascular Research Center, New Haven, CT, USA.ORCID 0000-0003-0348-7734
Rob KramsDepartment of Bioengineering, Queen Mary University of London, London, UK.
Johannes WaltenbergerDepartment of Cardiovascular Medicine, Medical Faculty, University of Münster, Münster, Germany.
Maria FragiadakiDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.
Victoria RidgerDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.
Sarah De ValBHF Centre of Regenerative Medicine, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.ORCID 0000-0002-2566-2348
Sheila E FrancisDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.ORCID 0000-0001-6552-0339
Timothy Ja ChicoDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.
Jovana Serbanovic-CanicDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.ORCID 0000-0002-8835-1491
Paul C EvansDepartment of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute for In Silico Medicine, and the Bateson Centre, University of Sheffield, Sheffield, UK.ORCID 0000-0001-7975-681X
Insigneo · GBUniversity of Illinois Chicago · USUniversity of Sheffield · GBQueen Mary University of London · GBSouthwest Medical University · CNUniversity of Cambridge · GBUniversity of Münster · DEUniversity of Oxford · GBYale University · US
Funding
Surgery / Physiology CoreP01HL107205 · NHLBI · YALE UNIVERSITY · PI SUAREZ, YAJAIRA · 2012 to 2022
$18.8MPrecision nanomedicine targeting novel endothelial mechano-sensing mechanismsR35HL161244 · NHLBI · UNIVERSITY OF CHICAGO · PI Yun Fang · 2022 to 2026
$4.0MVascular smooth muscle cell heterogeneity and diseaseR01HL152197 · NHLBI · YALE UNIVERSITY · PI SIMONS, MICHAEL, TELLIDES, GEORGE · 2021 to 2024
$3.3MBritish Heart Foundation FS/17/35/32929British Heart Foundation PG/17/56/33115British Heart Foundation PG/18/63/33968Medical Research Council MR/J007765/1Medical Research Council MR/T04201X/1NHLBI NIH HHS P01 HL107205NHLBI NIH HHS R01 HL152197NHLBI NIH HHS R35 HL161244
Abstract
Endothelial cell (EC) sensing of disturbed blood flow triggers atherosclerosis, a disease of arteries that causes heart attack and stroke, through poorly defined mechanisms. The Notch pathway plays a central role in blood vessel growth and homeostasis, but its potential role in sensing of disturbed flow has not been previously studied. Here, we show using porcine and murine arteries and cultured human coronary artery EC that disturbed flow activates the JAG1-NOTCH4 signaling pathway. Light-sheet imaging revealed enrichment of JAG1 and NOTCH4 in EC of atherosclerotic plaques, and EC-specific genetic deletion of
Indexed as
AtherosclerosisJagged-1 ProteinPlaque, AtheroscleroticReceptor, Notch4AnimalsCoronary VesselsEndothelial CellsHumansMiceSignal TransductionSwineJAG1 protein, humanJagged-1 ProteinNOTCH4 protein, humanReceptor, Notch4
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.