ArticleProceedings of the National Academy of Sciences of the United States of America2022
Disruption of mitochondria-sarcoplasmic reticulum microdomain connectomics contributes to sinus node dysfunction in heart failure.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- Mitochondrial cardiovascular diseases: molecular mechanisms, multi-omics exploration and therapeutic strategies.Journal of advanced research · 2026Review
- Bridging tradition and modernity: mitochondrial dynamics as a Traditional Chinese Medicine therapeutic target in cardiovascular disease.Chinese medicine · 2026Review
- Role of LONP1 in human diseases: molecular mechanisms and therapeutic potential.Cellular & molecular biology letters · 2026Review
- Mitochondria-associated membranes in heart failure: from molecular mechanisms to therapeutic targets.Frontiers in physiology · 2026Review
- The role of mitochondrial-associated endoplasmic reticulum membranes (MAMs) in diabetic microvascular complications: a review.Cell death & disease · 2025Review
- Stress-Induced calcium mishandling in cardiac (Patho)physiology.Cellular and molecular life sciences : CMLS · 2025Review
- PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias.Nature communications · 2025Article
- Calcium signalling and organelle crosstalk in cardiovascular disease: an interplay of cardiac cell death pathways.Molecular biology reports · 2025Review
- Sarcoplasmic reticulum-mitochondria microdomains: hugging and kissing in the heart.American journal of physiology. Cell physiology · 2025Review
- Aging and sinus node dysfunction: mechanisms and future directions.Clinical science (London, England : 1979) · 2025Review
- Current state of heart failure treatment: are mesenchymal stem cells and their exosomes a future therapy?Frontiers in cardiovascular medicine · 2025Review
- Article
- Structure-Function Relationship of the Ryanodine Receptor Cluster Network in Sinoatrial Node Cells.Cells · 2024Article
- Metabolic remodelling in atrial fibrillation: manifestations, mechanisms and clinical implications.Nature reviews. Cardiology · 2024Review
- Mitochondrial dysfunction in long COVID: mechanisms, consequences, and potential therapeutic approaches.GeroScience · 2024Review
- Profiling Reduced Expression of Contractile and Mitochondrial mRNAs in the Human Sinoatrial Node vs. Right Atrium and Predicting Their Suppressed Expression by Transcription Factors and/or microRNAs.International journal of molecular sciences · 2024Article
- Mitochondrial network remodeling of the diabetic heart: implications to ischemia related cardiac dysfunction.Cardiovascular diabetology · 2024Review
- Mitochondrial Structure and Function in Human Heart Failure.Circulation research · 2024Review
- Mitochondria-associated endoplasmic reticulum membrane (MAM): a dark horse for diabetic cardiomyopathy treatment.Cell death discovery · 2024Review
- Mitochondrial dysfunction is a key link involved in the pathogenesis of sick sinus syndrome: a review.Frontiers in cardiovascular medicine · 2024Review
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Authors and funding
19 authors at 5 institutions in 1 country.
Lu RenDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-9731-8562
Raghavender R GopireddyDepartment of Pharmacology, University of California, Davis, CA 95616.
Guy PerkinsNational Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA 92093.
Hao ZhangStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305.ORCID 0000-0002-2646-0959
Valeriy TimofeyevDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.
Yankun LyuDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-4387-8468
Daphne A DilorettoDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-2386-2119
Pauline TrinhDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.ORCID 0000-0001-8167-7504
Padmini SirishDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.
James L OvertonDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.
Wilson XuDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.
Nathan GraingerDepartment of Physiology and Membrane Biology, University of California, Davis, CA 95616.ORCID 0000-0002-9956-9592
Yang K XiangDepartment of Pharmacology, University of California, Davis, CA 95616.ORCID 0000-0003-1786-9143
Elena N DedkovaDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616.ORCID 0000-0002-0601-9816
Xiao-Dong ZhangDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.
Ebenezer N YamoahDepartment of Physiology and Cell Biology, University of Nevada, Reno, NV 89557.ORCID 0000-0002-9797-085X
Manuel F NavedoDepartment of Pharmacology, University of California, Davis, CA 95616.
Phung N ThaiDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.ORCID 0000-0001-7344-150X
Nipavan ChiamvimonvatDivision of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616.ORCID 0000-0001-9499-8817
University of California, Davis · USCardiovascular Institute of the South · USUniversity of Nevada, Reno · USUniversity of California San Diego · USVA Northern California Health Care System · US
Funding
Structural Analyses CoreP01AG051443 · NIA · UNIVERSITY OF NEVADA RENO · PI RUBIO-VALERO, MARIA-EULALIA · 2016 to 2025
$15.5MFunctional Interactions of Cardiac Ion ChannelsR01HL085844 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2007 to 2025
$7.3MTraining Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1MTranslational Study of Cardiac DysfunctionR01HL085727 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN, SIRISH, PADMINI · 2008 to 2022
$5.7MInner ear ion channels in healthy and diseased conditionsR01DC016099 · NIDCD · UNIVERSITY OF NEVADA RENO · PI EBENEZER N YAMOAH · 2017 to 2026
$4.7MCerebral Vascular Smooth Muscle Dysfunction in Alzheimer's DiseaseR01HL149127 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2019 to 2022
$2.7McAMP signaling in vascular smooth muscle in health and diseaseR01HL161872 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NAVEDO, MANUEL F · 2022 to 2025
$2.6MMechanisms of Growth Factor Responsiveness in the Aging Auditory SystemR01AG060504 · NIA · UNIVERSITY OF NEVADA RENO · PI FRITZSCH, BERND, YAMOAH, EBENEZER N · 2018 to 2022
$2.5MA prospective multiethnic HFpEF cohort from Californias Central ValleyU01HL160274 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, Nipavan Chiamvimonvat · 2021 to 2026
$2.3MDecoding the enigma of cardiac amplificationR01HL137228 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHIAMVIMONVAT, NIPAVAN · 2017 to 2020
$2.2MCalcium-dependent functions in Hair Cells and Spiral Ganglion NeuronsR01DC015135 · NIDCD · UNIVERSITY OF NEVADA RENO · PI GRATTON, MICHAEL ANNE NMI, YAMOAH, EBENEZER N · 2016 to 2020
$2.1MPRESBYCUSIS--BIOMEDICAL RISK FACTORSR01DC001525 · NIDCD · WASHINGTON UNIVERSITY · PI GATES, GEORGE A. · 1992 to 2005
$1.8MBLRD VA I01 BX000576BLRD VA I01 BX005100CSRD VA I01 CX001490NHLBI NIH HHS F32 HL149288NHLBI NIH HHS R01 HL085727NHLBI NIH HHS R01 HL085844NHLBI NIH HHS R01 HL137228NHLBI NIH HHS R01 HL147263NHLBI NIH HHS R01 HL149127NHLBI NIH HHS R01 HL155907NHLBI NIH HHS R01 HL161872NHLBI NIH HHS R56 HL138392NHLBI NIH HHS T32 HL086350NHLBI NIH HHS U01 HL160274NIA NIH HHS P01 AG051443NIA NIH HHS R01 AG060504NIDCD NIH HHS R01 DC001525NIDCD NIH HHS R01 DC004215NIDCD NIH HHS R01 DC015135NIDCD NIH HHS R01 DC016099
Abstract
The sinoatrial node (SAN), the leading pacemaker region, generates electrical impulses that propagate throughout the heart. SAN dysfunction with bradyarrhythmia is well documented in heart failure (HF). However, the underlying mechanisms are not completely understood. Mitochondria are critical to cellular processes that determine the life or death of the cell. The release of Ca
Indexed as
ConnectomeHeart FailureMitochondria, HeartSarcoplasmic ReticulumSick Sinus SyndromeSinoatrial NodeAnimalsMiceMyocytes, CardiacRyanodine Receptor Calcium Release ChannelRyanodine Receptor Calcium Release Channelbradycardiaheart failuremitochondriasinoatrial nodesinoatrial node dysfunction
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.