Evidence map›Paper›PMID 36044544›Full record

ArticleJournal of medicinal chemistry2022

2-(Fluoromethoxy)-4'-(

Javier García-Cárceles, Henar Vázquez-Villa, José Brea, David Ladron de Guevara-Miranda, Giovanni Cincilla, Melchor Sánchez-Martínez, Anabel Sánchez-Merino, Sergio Algar, María Teresa de Los Frailes, Richard S Roberts and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Javier García-CárcelesDepartamento de Química Orgánica, Universidad Complutense de Madrid, E-28040 Madrid, Spain.ORCID 0000-0003-4614-9639
Henar Vázquez-VillaDepartamento de Química Orgánica, Universidad Complutense de Madrid, E-28040 Madrid, Spain.ORCID 0000-0001-7911-3160
José BreaBiofarma Research Group, USEF Screening Platform, CIMUS, USC, E-15782 Santiago de Compostela, Spain.ORCID 0000-0002-5523-1979
David Ladron de Guevara-MirandaInstituto de Investigación Biomédica de Málaga (IBIMA), E-29010 Málaga, Spain.
Giovanni CincillaMolomics S.L., Parc Científic de Barcelona, Baldiri Reixac 4-8, E-08028 Barcelona, Spain.ORCID 0000-0002-5242-0707
Melchor Sánchez-MartínezMolomics S.L., Parc Científic de Barcelona, Baldiri Reixac 4-8, E-08028 Barcelona, Spain.ORCID 0000-0002-3674-8577
Anabel Sánchez-MerinoDepartamento de Química Orgánica, Universidad Complutense de Madrid, E-28040 Madrid, Spain.
Sergio AlgarDepartamento de Química Orgánica, Universidad Complutense de Madrid, E-28040 Madrid, Spain.ORCID 0000-0003-0933-5985
María Teresa de Los FrailesFundación Kærtor, Edificio EMPRENDIA, Planta 2, Oficina 4. Campus Vida, E-15706 Santiago de Compostela, Spain.
Richard S RobertsFundación Kærtor, Edificio EMPRENDIA, Planta 2, Oficina 4. Campus Vida, E-15706 Santiago de Compostela, Spain.
Juan A BallesterosVivia Biotech S.L., Parque Científico de Madrid, E-28760 Madrid, Spain.
Fernando Rodríguez de FonsecaInstituto de Investigación Biomédica de Málaga (IBIMA), E-29010 Málaga, Spain.
Bellinda BenhamúDepartamento de Química Orgánica, Universidad Complutense de Madrid, E-28040 Madrid, Spain.ORCID 0000-0002-0864-026X
María I LozaBiofarma Research Group, USEF Screening Platform, CIMUS, USC, E-15782 Santiago de Compostela, Spain.ORCID 0000-0003-4730-0863
María L López-RodríguezDepartamento de Química Orgánica, Universidad Complutense de Madrid, E-28040 Madrid, Spain.ORCID 0000-0001-8607-1085
Universidad Complutense de Madrid · ESCenter for Research in Molecular Medicine and Chronic Diseases · ESInstituto de Investigación Biomédica de Málaga · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tolerance development caused by dopamine replacement with l-DOPA and therapeutic drawbacks upon activation of dopaminergic receptors with orthosteric agonists reveal a significant unmet need for safe and effective treatment of Parkinson's disease. In search for selective modulators of the D

Indexed as

CocaineParkinson DiseaseAnimalsBiphenyl CompoundsDopamineDopamine AgentsDopamine AgonistsHumansIndazolesLevodopaLigandsMiceNitrofuransReceptors, DopamineReceptors, Dopamine D13-(5-nitrofuryl)-7-(5-nitrofurfurylidene)-3,3a,4,5,6,7-hexahydro-2H-indazolebiphenylBiphenyl CompoundsCocaineDopamineDopamine AgentsDopamine AgonistsIndazolesLevodopaLigandsNitrofuransReceptors, DopamineReceptors, Dopamine D1

Identifiers

PMID36044544
PMCPMC9511493
OpenAlexW4293785496

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.