SynthesisAnaesthesia2023
Effect of high-flow nasal oxygen on hypoxaemia during procedural sedation: a systematic review and meta-analysis.
Synthesis in Anaesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Efficacy and safety of endoscopy-specific dual-channel supraglottic airways for upper gastrointestinal endoscopic and transesophageal instrumentation procedures: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Efficacy and safety of supraglottic jet oxygenation and ventilation in Chinese patients undergoing bronchoscopic procedures: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Efficacy and safety of supraglottic jet oxygenation and ventilation to minimize sedation-related hypoxemia: a meta-analysis with GRADE approach.Systematic reviews · 2024Pooled it
- The effectiveness of transnasal high flow nasal cannula in bronchoscopy under sedation: a systematic review and meta-analysis.Frontiers in medicine · 2024Pooled it
- Use of optiflow THRIVE high-flow nasal oxygen system versus a non-rebreather oxygen delivery device in patients with increased risk of airway obstruction in interventional radiology procedures: a randomized pilot study.BMC anesthesiology · 2026Trial
- Efficacy and safety of ciprofol for gastroscopy in patients with obesity: a randomised clinical controlled trial using different weight-based dosing scales.BMC anesthesiology · 2025Trial
- High-flow nasal oxygen in a sedated patient with hypoxemia undergoing balloon kyphoplasty in the prone position.Journal of anesthesia · 2026Article
- High-flow versus low-flow nasal oxygen during procedural sedation for atrial fibrillation ablation: A randomised controlled trial.European journal of anaesthesiology and intensive care · 2026Article
- High-flow nasal oxygen in anesthesiology practice.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Review
- Effectiveness of High-Flow Nasal Oxygen vs. Standard Nasal Oxygen in Preventing Hypoxia During Procedural Sedation in Minor and Moderate Burn Patients: A Prospective Observational Study.Medicina (Kaunas, Lithuania) · 2026Observational
- High-Flow Nasal Oxygen in Contemporary Airway Management: Enhancing Physiological Safety in Anaesthesia-A Narrative Review.Healthcare (Basel, Switzerland) · 2026Review
- Glottic-level, anesthesia machine-based high-frequency ventilation as an oxygenation bridge for short pediatric gastroscopy under intravenous anesthesia: a nine-patient case series.Journal of anesthesia · 2026Article
- High-Flow Nasal Cannula Oxygen Therapy in Perioperative Respiratory Care: Application and Prospects.Journal of multidisciplinary healthcare · 2026Review
- The Effect of Deep Sedation with High Flow Nasal Oxygen Therapy on the Transcutaneous COSensors (Basel, Switzerland) · 2025Observational
- Article
- Evidence on Non-Invasive Respiratory Support During Flexible Bronchoscopy: A Narrative Review.Journal of clinical medicine · 2025Review
- Review
- Article
- High-flow nasal cannula is an expensive and clunky placebo: myth or maxim?Breathe (Sheffield, England) · 2024Review
- Continuous positive airway pressure is unsafe for radiofrequency ablation of lung cancer under sedation: a randomised controlled trial.Insights into imaging · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a systematic review to evaluate the effect of high-flow nasal oxygen and conventional oxygen therapy during procedural sedation amongst adults and children. We searched MEDLINE, EMBASE and CINAHL for randomised controlled trials that reported the effects of high-flow nasal oxygen during procedural sedation. The primary outcome measure was hypoxaemia and the secondary outcomes were minimum oxygen saturation; hypercarbia; requirement for airway manoeuvres; and procedure interruptions. The quality of evidence was assessed using the revised Cochrane risk-of bias tool and grading of recommendations, assessment, development and evaluation (GRADE). Nineteen randomised controlled trials (4121 patients) including three in children were included. Administration of high-flow nasal oxygen reduced hypoxaemia, risk ratio (95%CI) 0.37 (0.24-0.56), p < 0.001; minor airway manoeuvre requirements, risk ratio (95%CI) 0.26 (0.11-0.59), p < 0.001; procedural interruptions, risk ratio (95%CI) 0.17 (0.05-0.53), p = 0.002; and increased minimum oxygen saturation, mean difference (95%CI) 4.1 (2.70-5.50), p < 0.001; as compared with the control group. High-flow nasal oxygen had no impact on hypercarbia, risk ratio (95%CI) 1.24 (0.97-1.58), p = 0.09, I
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.