Evidence map›Paper›PMID 36044277›Full record

ArticleAging2022

Systemic lipolysis promotes physiological fitness in

Linshan Shang, Elizabeth Aughey, Huiseon Kim, Timothy D Heden, Lu Wang, Charles P Najt, Nicholas Esch, Sophia Brunko, Juan E Abrahante, Marissa Macchietto and 5 more

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Linshan ShangDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Elizabeth AugheyDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Huiseon KimDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Timothy D HedenDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Lu WangDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105, USA.
Charles P NajtDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Nicholas EschDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Sophia BrunkoDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Juan E AbrahanteUniversity of Minnesota Informatics Institute, Minneapolis, MN 55455, USA.
Marissa MacchiettoMinnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Mara T MashekDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
Todd FairbanksDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Daniel E L PromislowDepartment of Biology, University of Washington, Seattle, WA 98195, USA.
Thomas P NeufeldDepartment of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA.
Douglas G MashekDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
University of Minnesota · USUniversity of Washington · US

Funding

University of Washington Nathan Shock Center of Excellence in the Basic Biology of AgingP30AG013280 · NIA · UNIVERSITY OF WASHINGTON · PI Michael MacCoss · 1995 to 2026
$27.1M
MUFA-SIRT1 signaling as a central node regulating healthspanR01AG069768 · NIA · UNIVERSITY OF MINNESOTA · PI MASHEK, DOUGLAS G · 2020 to 2024
$1.9M
Metabolome-Genome Associations for Determining Mechanisms of Aging in DrosophilaR01AG049494 · NIA · UNIVERSITY OF WASHINGTON · PI PROMISLOW, DANIEL EDWARD · 2015 to 2019
$1.8M
Role of ATGL and lipid metabolism in healthspanR01AG055452 · NIA · UNIVERSITY OF MINNESOTA · PI MASHEK, DOUGLAS G · 2017 to 2021
$1.6M
Mechanisms of TOR-dependent control of autophagy in DrosophilaR01GM136835 · NIGMS · UNIVERSITY OF MINNESOTA · PI NEUFELD, THOMAS P. · 2021 to 2024
$1.3M
Perilipin 5: Linking lipid droplets to nutrient sensing and healthy agingR00AG070104 · NIA · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI Charles P Najt · 2024 to 2026
$711k
Multiplexed UPLC-MS/MS System for Advanced Target MetabolomicsS10OD021562 · OD · UNIVERSITY OF WASHINGTON · PI RAFTERY, DANIEL · 2016 to 2016
$596k
Glycophagy in liver and skeletal muscle insulin sensitivity and energy metabolismK01DK125258 · NIDDK · UNIVERSITY OF MINNESOTA · PI HEDEN, TIMOTHY D. · 2020 to 2022
$489k
Perilipin 5: Linking lipid droplets to nutrient sensing and healthy agingK99AG070104 · NIA · UNIVERSITY OF MINNESOTA · PI NAJT, CHARLES P · 2021 to 2022
$205k
Role of ATGL and lipid metabolism in healthspanR56AG051599 · NIA · UNIVERSITY OF MINNESOTA · PI MASHEK, DOUGLAS G · 2016 to 2016
$198k
NIA NIH HHS K99 AG070104NIA NIH HHS P30 AG013280NIA NIH HHS R00 AG070104NIA NIH HHS R01 AG049494NIA NIH HHS R01 AG055452NIA NIH HHS R01 AG069768NIA NIH HHS R56 AG051599NIDDK NIH HHS K01 DK125258NIGMS NIH HHS R01 GM136835NIH HHS S10 OD021562
6 · The paper itself

Abstract

Since interventions such as caloric restriction or fasting robustly promote lipid catabolism and improve aging-related phenotypical markers, we investigated the direct effect of increased lipid catabolism via overexpression of

Indexed as

Drosophila melanogasterDrosophila ProteinsAnimalsDrosophilaFemaleLipolysisLongevityTriglyceridesDrosophila ProteinsTriglyceridesbrummerlipolysisphysiological fitnessproteostasisstress resistance

Identifiers

PMID36044277
PMCPMC9467406
OpenAlexW4293705137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.