Evidence map›Paper›PMID 36044259›Full record

ArticleeLife2022

Diverse states and stimuli tune olfactory receptor expression levels to modulate food-seeking behavior.

Ian G McLachlan, Talya S Kramer, Malvika Dua, Elizabeth M DiLoreto, Matthew A Gomes, Ugur Dag, Jagan Srinivasan, Steven W Flavell

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
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  8. When noncanonical olfaction is optimal.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  10. bioRxiv : the preprint server for biology · 2025
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  16. UPReLife · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Ian G McLachlanPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0002-1897-7288
Talya S Kramer *Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0002-3763-511X
Malvika Dua *Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.
Elizabeth M DiLoretoDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, United States.
Matthew A GomesPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.
Ugur DagPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0001-6937-5722
Jagan SrinivasanDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, United States.ORCID 0000-0001-5449-7938
Steven W FlavellPicower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, United States.ORCID 0000-0001-9464-1877
Massachusetts Institute of Technology · USWorcester Polytechnic Institute · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Neuromodulatory control of collective circuit dynamics in C. elegansR01NS104892 · NINDS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FLAVELL, STEVEN WILLEM · 2017 to 2021
$2.1M
Functional connectome of sex-specific processing of social cuesR01DC016058 · NIDCD · WORCESTER POLYTECHNIC INSTITUTE · PI SRINIVASAN, JAGAN · 2017 to 2021
$1.6M
NIDCD NIH HHS R01 DC016058NIH HHS P40 OD010440NINDS NIH HHS R01 NS104892
6 · The paper itself

Abstract

Animals must weigh competing needs and states to generate adaptive behavioral responses to the environment. Sensorimotor circuits are thus tasked with integrating diverse external and internal cues relevant to these needs to generate context-appropriate behaviors. However, the mechanisms that underlie this integration are largely unknown. Here, we show that a wide range of states and stimuli converge upon a single

Indexed as

Caenorhabditis elegans ProteinsOlfactory Receptor NeuronsReceptors, OdorantAnimalsCaenorhabditis elegansSmellCaenorhabditis elegans ProteinsReceptors, Odorantbehavioral statesC. elegansintegrationneural circuitsneuroscienceolfactionsensorimotor

Identifiers

PMID36044259
PMCPMC9433090
OpenAlexW4293835557

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.