ArticleJournal of the American Chemical Society2022
Copper Hydride-Catalyzed Enantioselective Olefin Hydromethylation.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- Catalytic Asymmetric Hydration of Alkenes.Journal of the American Chemical Society · 2026Article
- Article
- Enantioselective Copper-Catalyzed Synthesis of Hydroxylamines via Hydrofunctionalization of Alkenes using Nitroalkanes.Journal of the American Chemical Society · 2026Article
- Dynamic radical recombination enabling stereodivergent construction of spirocycles with nonadjacent stereocenters.Nature communications · 2025Article
- Diversity-Oriented Method Development: Multifunctional Homoallylic Amines and Azabicyclooctanes Bearing a Bridgehead Enamine.Journal of the American Chemical Society · 2025Article
- London Dispersion as a Design Element in Molecular Catalysis.Journal of the American Chemical Society · 2025Review
- Copper Hydride-Catalyzed Net Hydroformylation of Unactivated Terminal Olefins.Organic letters · 2025Article
- Non-enzymatic methylcyclization of alkenes.Nature chemistry · 2025Article
- Metal-Hydride C-C Cross-Coupling of Alkenes Through a Double Outer-Sphere Mechanism.The Journal of organic chemistry · 2024Review
- Regio- and Enantioselective Hydromethylation of 3-Pyrrolines and Glycals Enabled by Cobalt Catalysis.JACS Au · 2024Article
- CuH-Catalyzed Regio- and Enantioselective Formal Hydroformylation of Vinyl Arenes.Journal of the American Chemical Society · 2024Article
- Engaging Alkenes in Metallaphotoredox: A Triple Catalytic, Radical Sorting Approach to Olefin-Alcohol Cross-Coupling.Journal of the American Chemical Society · 2024Article
- Enantioselective synthesis of chiral α,α-dialkyl indoles and related azoles by cobalt-catalyzed hydroalkylation and regioselectivity switch.Nature communications · 2024Article
- Stereoselective Synthesis of Trisubstituted Alkenes via Copper Hydride-Catalyzed Alkyne Hydroalkylation.Journal of the American Chemical Society · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The enantioselective installation of a methyl group onto a small molecule can result in the significant modification of its biological properties. While hydroalkylation of olefins represents an attractive approach to introduce alkyl substituents, asymmetric hydromethylation protocols are often hampered by the incompatibility of highly reactive methylating reagents and a lack of general applicability. Herein, we report an asymmetric olefin hydromethylation protocol enabled by CuH catalysis. This approach leverages methyl tosylate as a methyl source compatible with the reducing base-containing reaction environment, while a catalytic amount of iodide ion transforms the methyl tosylate
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