ReviewJournal of the American Chemical Society2022
The Implications of the Brønsted Acidic Properties of Crabtree-Type Catalysts in the Asymmetric Hydrogenation of Olefins.
Review in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Iridium-Catalyzed Asymmetric Hydrogenation of Carbocation Precursors via Wagner-Meerwein Rearrangement.Journal of the American Chemical Society · 2026Article
- Tandem Oligomerization-Hydrogenation Using Brønsted Acidic Iridium Hydride Catalysts.Organometallics · 2025Article
- Data-Driven Insights into the Transition-Metal-Catalyzed Asymmetric Hydrogenation of Olefins.The Journal of organic chemistry · 2024Article
- Asymmetric Synthesis and Applications of Chiral Organoselenium Compounds: A Review.Molecules (Basel, Switzerland) · 2024Review
- Diastereoselective Hydrogenation of Tetrasubstituted Olefins using a Heterogeneous Pt-Ni Alloy Catalyst.Angewandte Chemie (International ed. in English) · 2024Article
- Access to Enantiomerically PureMolecules (Basel, Switzerland) · 2023Article
- A 13-million turnover-number anionic Ir-catalyst for a selective industrial route to chiral nicotine.Nature communications · 2023Article
- Iridium-Catalyzed Double Convergent 1,3-Rearrangement/Hydrogenation of Allylic Alcohols.Journal of the American Chemical Society · 2023Article
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Authors and funding
2 authors.
Funding
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Abstract
Chiral iridium complexes derived from Crabtree's catalyst are highly useful in modern hydrogenations of olefins attributed to high reactivity, stereoselectivity, and stability. Despite that these precatalysts are pH neutral, the reaction mixtures turn acidic under hydrogenation conditions. This Perspective is devoted to the implications of the intrinsic Brønsted acidity of catalytic intermediates in asymmetric hydrogenation of olefins. Despite that the acidity has often been used only as a rationale for side-product formation, more recent methodologies have started to use this property advantageously. We hope that this Perspective serves as a stimulant for the development of such compelling and new asymmetric hydrogenations. The inherent scientific opportunities in utilizing or annihilating the generated Brønsted acid are enormous, and potential new innovations are outlined toward the end.
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