ArticleJournal of water and health2022
Modeling infection from SARS-CoV-2 wastewater concentrations: promise, limitations, and future directions.
Article in Journal of water and health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review and meta-analysis of enteric virus shedding in human excretions.EBioMedicine · 2025Pooled it
- Bio-Rad and QIAGEN digital PCR platforms provide equivalent quantification for wastewater-based SARS-CoV-2 surveillance.Applied and environmental microbiology · 2026Article
- Environmental Surveillance of Vector-Borne Diseases in a Non-Sewered System: A Case Study in Mozambique.Environmental science & technology · 2025Article
- Turning analysis into action: opportunities and challenges in implementing wastewater science for public health decision-making.Frontiers in public health · 2025Article
- The value of environmental surveillance for pandemic response.Scientific reports · 2024Article
- Estimating rates of change to interpret quantitative wastewater surveillance of disease trends.The Science of the total environment · 2024Article
- The first detection of SARS-CoV-2 RNA in the wastewater of Bucharest, Romania.Scientific reports · 2024Article
- The National Wastewater Surveillance System (NWSS): From inception to widespread coverage, 2020-2022, United States.The Science of the total environment · 2024Article
- Persistence of human respiratory viral RNA in wastewater-settled solids.Applied and environmental microbiology · 2024Article
- Quantitatively assessing early detection strategies for mitigating COVID-19 and future pandemics.Nature communications · 2023Article
- Characterizing Spatial Information Loss for Wastewater Surveillance Using crAssphage: Effect of Decay, Temperature, and Population Mobility.Environmental science & technology · 2023Article
- Quantitatively assessing early detection strategies for mitigating COVID-19 and future pandemics.medRxiv : the preprint server for health sciences · 2023Article
- The Protective Effect of Virus Capsids on RNA and DNA Virus Genomes in Wastewater.Environmental science & technology · 2023Article
- Adsorption of Respiratory Syncytial Virus, Rhinovirus, SARS-CoV-2, and F+ Bacteriophage MS2 RNA onto Wastewater Solids from Raw Wastewater.Environmental science & technology · 2023Article
- The hidden risk of microplastic-associated pathogens in aquatic environments.Eco-Environment & Health · 2023Review
- Longitudinal and quantitative fecal shedding dynamics of SARS-CoV-2, pepper mild mottle virus, and crAssphage.mSphere · 2023Article
- Application of wastewater-based surveillance and copula time-series model for COVID-19 forecasts.The Science of the total environment · 2023Article
- Significance of wastewater surveillance in detecting the prevalence of SARS-CoV-2 variants and other respiratory viruses in the community - A multi-site evaluation.One health (Amsterdam, Netherlands) · 2023Article
- Wastewater concentrations of human influenza, metapneumovirus, parainfluenza, respiratory syncytial virus, rhinovirus, and seasonal coronavirus nucleic-acids during the COVID-19 pandemic: a surveillance study.The Lancet. Microbe · 2023Article
- The dynamic relationship between COVID-19 cases and SARS-CoV-2 wastewater concentrations across time and space: Considerations for model training data sets.The Science of the total environment · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Estimating total infection levels, including unreported and asymptomatic infections, is important for understanding community disease transmission. Wastewater can provide a pooled community sample to estimate total infections that is independent of case reporting biases toward individuals with moderate to severe symptoms and by test-seeking behavior and access. We derive three mechanistic models for estimating community infection levels from wastewater measurements based on a description of the processes that generate SARS-CoV-2 RNA signals in wastewater and accounting for the fecal strength of wastewater through endogenous microbial markers, daily flow, and per-capita wastewater generation estimates. The models are illustrated through two case studies of wastewater data collected during 2020-2021 in Virginia Beach, VA, and Santa Clara County, CA. Median simulated infection levels generally were higher than reported cases, but at times, were lower, suggesting a discrepancy between the reported cases and wastewater data, or inaccurate modeling results. Daily simulated infection estimates showed large ranges, in part due to dependence on highly variable clinical viral fecal shedding data. Overall, the wastewater-based mechanistic models are useful for normalization of wastewater measurements and for understanding wastewater-based surveillance data for public health decision-making but are currently limited by lack of robust SARS-CoV-2 fecal shedding data.
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