Evidence map›Paper›PMID 36044175›Full record

ArticleProbiotics and antimicrobial proteins2023

Neuroprotective Effects of Probiotic Lactobacillus reuteri GMNL-263 in the Hippocampus of Streptozotocin-Induced Diabetic Rats.

Jing-Ying Lin, Bruce Chi-Kang Tsai, Hui-Chuan Kao, Chien-Yi Chiang, Yun-An Chen, William Shao-Tsu Chen, Tsung-Jung Ho, Chun-Hsu Yao, Wei-Wen Kuo, Chih-Yang Huang

Abstract read
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In one paragraph

Article in Probiotics and antimicrobial proteins, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Life (Basel, Switzerland) · 2026
    Article
  6. Therapeutic potential ofFrontiers in pharmacology · 2025
    Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Jing-Ying LinDepartment of Medical Imaging and Radiological Science, Central Taiwan University of Science and Technology, Taichung, Taiwan.
Bruce Chi-Kang TsaiCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Hui-Chuan KaoDepartment of Public Health, Tzu Chi University, Hualien, Taiwan.
Chien-Yi ChiangCardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Yun-An ChenDepartment of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.
William Shao-Tsu ChenDepartment of Psychiatry, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Tsung-Jung HoDepartment of Chinese Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
Chun-Hsu YaoDepartment of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan.
Wei-Wen Kuo *Department of Biological Science and Technology, College of Life Sciences, China Medical University, Taichung, Taiwan.
Chih-Yang Huang *Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. cyhuang@mail.cmu.edu.tw.ORCID http://orcid.org/0000-0003-2347-0411
Tzu Chi University · TWAsia University · TWChina Medical University · TWTzu Chi Foundation · TWCentral Taiwan University of Science and Technology · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes-related brain complications have been reported in clinical patients and experimental models. The objective of the present study was to investigate the neuroprotective mechanisms of Lactobacillus reuteri GMNL-263 in streptozotocin (STZ)-induced diabetic rats. In this study, three different groups, namely control group, STZ-induced (55 mg/kg streptozotocin intraperitoneally) diabetic rats (DM), and DM rats treated with Lactobacillus reuteri GMNL-263 (1 × 10

Indexed as

Diabetes Mellitus, ExperimentalLimosilactobacillus reuteriNeuroprotective AgentsProbioticsAnimalsHippocampusRatsStreptozocinNeuroprotective AgentsStreptozocinDiabetic mellitusHyperglycemiaLactic acid bacteriaLactobacillus reuteriStreptozotocin

Identifiers

PMID36044175
OpenAlexW4293770879

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.