Evidence map›Paper›PMID 36044164›Full record

ArticleJournal of assisted reproduction and genetics2022

High expression of CFTR in cumulus cells from mature oocytes is associated with high-quality of oocyte and subsequent embryonic development.

Jing Yang, Ming-Juan Wang, Wen-Jie Huang, Qian Zhou, Xue Ying, Yong-Hong Tian, Yi-Min Zhu, Yong-Chao Lu

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of assisted reproduction and genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jing Yang *Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, 310006, Zhejiang, China.
Ming-Juan Wang *Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, 310006, Zhejiang, China.
Wen-Jie HuangDepartment of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, 310006, Zhejiang, China.
Qian ZhouDepartment of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, 310006, Zhejiang, China.
Xue YingDepartment of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, 310006, Zhejiang, China.
Yong-Hong TianDepartment of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, 310006, Zhejiang, China.
Yi-Min ZhuDepartment of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, 310006, Zhejiang, China. zhuyimin@zju.edu.cn.
Yong-Chao LuDepartment of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, 1 Xueshi Road, Hangzhou, 310006, Zhejiang, China. 5312055@zju.edu.cn.ORCID http://orcid.org/0000-0003-1883-0152
Women's Hospital, School of Medicine, Zhejiang University · CNShanghai Ninth People's Hospital · CN

Funding

National Key Research and Development Program of China (2018YFC1003202)National Natural Science Foundation of China (81671418)
6 · The paper itself

Abstract

objectiveThe purpose of this study was to explore the association of expression of cystic fibrosis transmembrane conductance regulator (CFTR) in cumulus cells (CCs) from mature oocytes with oocyte quality and embryonic development.

methodsA total of 338 infertile women who underwent ovarian stimulation cycle of oocyte retrieval in Zhejiang University School of Medicine were retrospectively enrolled in this study. The relative mRNA expression levels of CFTR, bone morphogenetic protein 15 (BMP15), and growth differentiation factor 9 (GDF9) in CCs were detected by qPCR technology. ROC curve was applied for the diagnosis of oocyte maturation. The serum levels of anti-Müllerian hormone (AMH), E

resultsThe mRNA expression levels of CFTR in CCs were significantly increased in metaphase II (MII) oocytes compared to that in metaphase I (MI) or germinal vesicle (GV) oocytes. The ROC curve analysis illustrated that CFTR mRNA expression could efficiently discriminate MII oocytes from MI or GV oocytes (AUC = 0.954), and revealed that 0.695 RQU is the optimal cut-off value for diagnosis. So the cut-off value of 2

conclusionsThis study suggests that CFTR expression in CCs is associated with the developmental potential of human oocytes.

Indexed as

Cumulus CellsInfertility, FemaleAndrostenedioneAnti-Mullerian HormoneBone Morphogenetic Protein 15Cystic Fibrosis Transmembrane Conductance RegulatorEmbryonic DevelopmentFemaleFollicle Stimulating HormoneGrowth Differentiation Factor 9HumansLuteinizing HormoneOocytesPregnancyRetrospective StudiesRNA, MessengerAndrostenedioneAnti-Mullerian HormoneBone Morphogenetic Protein 15CFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorFollicle Stimulating HormoneGrowth Differentiation Factor 9Luteinizing HormoneRNA, MessengerCFTRCumulus cellEmbryoInfertilityIn vitro fertilizationOocytes

Identifiers

PMID36044164
PMCPMC9596676
OpenAlexW4293727349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.