SynthesisEndocrine pathology2022
Thyroid Nodules with Indeterminate FNAC According to the Italian Classification System: Prevalence, Rate of Operation, and Impact on Risk of Malignancy. An Updated Systematic Review and Meta-analysis.
Synthesis in Endocrine pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 24 citations in OpenAlex.
- Radiomics and machine learning analysis of ultrasound images in Bethesda IV thyroid nodules: a retrospective monocentric study.Updates in surgery · 2026Article
- Article
- Comprehensive evaluation of TIR 3B thyroid nodules: Clinical, Ultrasonographical and Cytological features for prediction of malignancy.Endocrine · 2026Article
- Article
- Cytopathological Findings of Axillary Lymph Nodes in Patients with Breast Cancer in Correlation with Ultrasound Findings.Iranian journal of pathology · 2026Article
- The role of artificial intelligence in thyroid cytology of indeterminate nodules: from digital cytology to multimodal precision triage.Frontiers in endocrinology · 2026Review
- Trends in Thyroid Fine-Needle Aspiration Cytology - Results from the Italian Cytopathology Committee National Practice Survey.Pathologica · 2025Article
- Ultrasound Pattern of Indeterminate Thyroid Nodules with Prevalence of Oncocytes.Journal of clinical medicine · 2025Article
- Analysis of histological features and recurrence risk assessment of papillary thyroid carcinoma according to presurgery FNAC category.Updates in surgery · 2025Article
- Natural History of Cytologically Low-Risk Indeterminate Thyroid Nodules.The Journal of clinical endocrinology and metabolism · 2025Article
- Clinical management of indeterminate thyroid nodules needs to be revisited. New evidence for a personalized approach to the problem.Journal of endocrinological investigation · 2025Observational
- Improving Diagnostic Accuracy of Indeterminate Thyroid Fine-Needle Aspiration Using Results of Ultrasound Examination, Cyclin D1 Immunostaining, and Molecular Testing.Acta cytologica · 2025Article
- Review
- Autoimmune Thyroid Disease and Differentiated Thyroid Carcinoma: A Review of the Mechanisms That Explain an Intriguing and Exciting Relationship.World journal of oncology · 2024Review
- An eXplainable Artificial Intelligence analysis of Raman spectra for thyroid cancer diagnosis.Scientific reports · 2023Article
- Indeterminate Thyroid Nodules: From Cytology to Molecular Testing.Diagnostics (Basel, Switzerland) · 2023Review
- Article
- Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study.The lancet. Diabetes & endocrinology · 2023Article
- Ultrasound Parameters Can Accurately Predict the Risk of Malignancy in Patients with "Indeterminate TIR3b" Cytology Nodules: A Prospective Study.International journal of molecular sciences · 2023Article
- An Indeterminate for Malignancy FNA Report Does Not Increase the Surgical Risk of Incidental Thyroid Carcinoma.Cancers · 2022Article
Corrections and comments
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Authors and funding
6 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A thyroid nodule classified as indeterminate on fine-needle aspiration cytology (FNAC), hereafter referred to as an indeterminate thyroid nodule (ITN), represents a clinical dilemma. The Italian Consensus for the Classification and Reporting of Thyroid Cytology (ICCRTC) divides ITNs into low- and high-risk categories (i.e., TIR3A and TIR3B, respectively) to better manage patients. This study aimed to achieve high-evidence estimates of the prevalence, rate of operation, and risk of malignancy of ITNs, including TIR3A and TIR3B ITNs. This systematic review was conducted according to MOOSE to retrieve all original studies citing ICCRTC. The last search was performed in February 2022. The risk of bias of the included studies was assessed. Separate proportion meta-analyses were performed with a random-effect model using OpenMeta[Analyst]. The online search processed 271 studies, and 33 were finally considered. First, the cancer prevalence among ITNs was 32.4%. Second, the cancer prevalence among TIR3As was 12.4%, with heterogeneity (I
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.