Evidence map›Paper›PMID 36044087›Full record

ArticleMikrochimica acta2022

Co, N co-doped porous carbon-based nanozyme as an oxidase mimic for fluorescence and colorimetric biosensing of butyrylcholinesterase activity.

Wenying Sun, Nan Wang, Xiaobin Zhou, Yuxuan Sheng, Xingguang Su

Abstract read
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In one paragraph

Article in Mikrochimica acta, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Wenying SunDepartment of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China.
Nan WangDepartment of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China.
Xiaobin ZhouDepartment of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China.
Yuxuan ShengDepartment of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China.
Xingguang SuDepartment of Analytical Chemistry, College of Chemistry, Jilin University, Changchun, 130012, China. suxg@jlu.edu.cn.ORCID 0000-0001-9856-4653
Jilin University · CN

Funding

National Natural Science Foundation of China No. 21575048National Natural Science Foundation of China No. 21775052Science and Technology Development project of Jilin province, China No. 20180414013GH
6 · The paper itself

Abstract

A Co, N co-doped porous carbon-based nanozyme (Co-N-C nanozyme) has been fabricated. Taking advantages of the excellent oxidase catalytic activity and significant stability of Co-N-C nanozyme, we propose a fluorescence and colorimetric system based on Co-N-C nanozyme and red-emitting carbon quantum dots (RCDs) for butyrylcholinesterase (BChE) sensing. As the chromogenic substrate 3,3',5,5'-tetramethylbenzidine (TMB) was catalyzed and oxidized by Co-N-C nanozyme, the generated oxTMB had a new absorption peak at 652 nm, which resulted in the significant quenching of the fluorescence of the carbon quantum dots at 610 nm. Under the catalysis of BChE, thiocholine was generated from the hydrolysis of S-butyrylthiocholine iodide (BTCh), and the as-generated thiocholine effectively inhibited the oxidation of TMB catalyzed by Co-N-C nanozyme, leading to a decrease of the absorption of oxTMB at 652 nm and effective fluorescence recovery of RCDs. By measuring the absorbance of produced oxTMB at 652 nm and the fluorescence of RCDs at 610 nm, the fluorescence and colorimetric system both exhibited an outstanding linear response to the activity of BChE in the range 0.5 to 40 U L

Indexed as

Biosensing TechniquesButyrylcholinesteraseColorimetryCarbonHumansNanostructuresOxidoreductasesPorosityThiocholineButyrylcholinesteraseCarbonOxidoreductasesThiocholineButyrylcholinesteraseCarbon quantum dotsFluorescence and colorimetric biosensingMetal–organic frameworkNanozyme

Identifiers

PMID36044087
OpenAlexW4293764396

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.