Evidence map›Paper›PMID 36043878›Full record

ArticleMicrobiology spectrum2022

Comparative Analysis of Clinical and Genomic Characteristics of Hypervirulent Klebsiella pneumoniae from Hospital and Community Settings: Experience from a Tertiary Healthcare Center in India.

Stephen Raj, Tanya Sharma, Dibyabhaba Pradhan, Sonu Tyagi, Hitender Gautam, Harpreet Singh, Seema Sood, Benu Dhawan, Bimal Kumar Das, Arti Kapil and 2 more

Open access · goldAbstract read
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 3 pooled it
2.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. A systematic review of hypervirulentFrontiers in medicine · 2025
    Pooled it
  4. Article
  5. Article
  6. Review
  7. Multidrug-resistantNew microbes and new infections · 2026
    Article
  8. Article
  9. Article
  10. Carbapenemase-producing hypervirulentJournal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2026
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Multiplex PCR assay for the rapid detection ofJournal of medical microbiology · 2025
    Article
  16. Article
  17. Prevalence, Risk Factors, and Clinical Outcomes of HypervirulentIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025
    Article
  18. Article
  19. CombatingFrontiers in cellular and infection microbiology · 2025
    Review
  20. Genome assembly ofFrontiers in microbiology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Stephen RajDepartment of Microbiology, All India Institute of Medical Sciencesgrid.413618.9, New Delhi, India.
Tanya SharmaICMR AIIMS Computational Genomics Centre, Division of Biomedical Informatics, Indian Council of Medical Researchgrid.19096.37, New Delhi, India.
Dibyabhaba PradhanICMR AIIMS Computational Genomics Centre, Division of Biomedical Informatics, Indian Council of Medical Researchgrid.19096.37, New Delhi, India.
Sonu TyagiDepartment of Microbiology, All India Institute of Medical Sciencesgrid.413618.9, New Delhi, India.
Hitender GautamDepartment of Microbiology, All India Institute of Medical Sciencesgrid.413618.9, New Delhi, India.ORCID 0000-0002-1409-1543
Harpreet SinghICMR AIIMS Computational Genomics Centre, Division of Biomedical Informatics, Indian Council of Medical Researchgrid.19096.37, New Delhi, India.
Seema SoodDepartment of Microbiology, All India Institute of Medical Sciencesgrid.413618.9, New Delhi, India.
Benu DhawanDepartment of Microbiology, All India Institute of Medical Sciencesgrid.413618.9, New Delhi, India.
Bimal Kumar DasDepartment of Microbiology, All India Institute of Medical Sciencesgrid.413618.9, New Delhi, India.
Arti KapilDepartment of Microbiology, All India Institute of Medical Sciencesgrid.413618.9, New Delhi, India.
Rama ChaudhryDepartment of Microbiology, All India Institute of Medical Sciencesgrid.413618.9, New Delhi, India.ORCID 0000-0002-7381-1504
Sarita MohapatraDepartment of Microbiology, All India Institute of Medical Sciencesgrid.413618.9, New Delhi, India.ORCID 0000-0002-8311-4112
All India Institute of Medical Sciences · INIndian Council of Medical Research · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypervirulent Klebsiella pneumoniae (hvKp) is a hypermucoviscous phenotype of classical Klebsiella pneumoniae (cKp) that causes serious infections in the community. The recent emergence of multidrug-resistant hvKp isolates (producing extended-spectrum beta-lactamases and carbapenemases) along with other virulence factors in health care settings has become a clinical crisis. Here, we aimed to compare the distribution of virulence determinants and antimicrobial resistance (AMR) genes in relation to various sequence types (STs) among the clinical hvKp isolates from both settings, to reinforce our understanding of their epidemiology and pathogenic potential. A total of 120 K. pneumoniae isolates confirmed by matrix-assisted laser desorption ionization-time of flight mass spectrometry were selected. hvKp was phenotypically identified by string test and genotypically confirmed by the presence of the

Indexed as

Klebsiella InfectionsKlebsiella pneumoniaeAnti-Bacterial Agentsbeta-LactamasesGenomicsHumansTertiary Care CentersTertiary Health CareVirulence FactorsAnti-Bacterial Agentsbeta-LactamasesVirulence Factorsantimicrobial resistance (AMR)community settingshealth care settingshypervirulent Klebsiella pneumoniae (hvKp)virulence geneswhole-genome sequencing (WGS)

Identifiers

PMID36043878
PMCPMC9602566
OpenAlexW4293755357

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.