Evidence map›Paper›PMID 36043564›Full record

ArticleBrazilian dental journal

Temporomandibular disorder in construction workers associated with ANKK1 and DRD2 genes.

Samantha Schaffer Pugsley Baratto, Michelle Nascimento Meger, Vânia Camargo, Gisele Maria Correr Nolasco, Natanael Henrique Ribeiro Mattos, Liliane Roskamp, José Stechman-Neto, Isabela Ribeiro Madalena, Erika Calvano Küchler, Flares Baratto-Filho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brazilian dental journal. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Investigating the impact of polymorphisms in theFrontiers in oral health · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Samantha Schaffer Pugsley BarattoSchool of Dentistry, UniDomBosco University Center, Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0001-6682-5601
Michelle Nascimento MegerSchool of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0002-1776-2373
Vânia CamargoSchool of Health Sciences, Positivo University, Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0003-1840-0101
Gisele Maria Correr NolascoSchool of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0002-5032-0948
Natanael Henrique Ribeiro MattosSchool of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0003-2755-2270
Liliane RoskampSchool of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0002-2331-0090
José Stechman-NetoSchool of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0002-0259-2420
Isabela Ribeiro MadalenaSchool of Dentistry, University of the Joinville Region, Joinville, Santa Catarina, Brazil.ORCID http://orcid.org/0000-0002-4486-1318
Erika Calvano KüchlerSchool of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0001-5351-2526
Flares Baratto-FilhoSchool of Dentistry, University of Tuiuti of Paraná, Curitiba, Paraná, Brazil.ORCID http://orcid.org/0000-0002-5649-7234
Universidade Tuiuti do Paraná · BRUniversidade Federal de Juiz de Fora · BRUniversidade Federal do Paraná · BRUniversidade Positivo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The study aimed to explore the influence of genetic polymorphisms in ANKK1 and DRD2 on the signs and symptoms of temporomandibular disorder (TMD) in construction workers. This cross-sectional study included only male subjects. All construction workers were healthy and over 18 years age. Illiterate workers and functionally illiterate workers were excluded. The diagnosis of TMD was established according to the Research Diagnostic Criteria for TMD (RDC/TMD). Genomic DNA was used to evaluate the genetic polymorphisms ANKK1 (rs1800497) and DRD2 (rs6275; rs6276) using Real-Time PCR. Chi-square or Fisher exact tests were used to evaluate genotypes and allele distribution among the studied phenotypes. The established alpha of this study was 5%. The sample included a total of 115 patients. The age of the patients ranged from 19 to 70 years (mean age 38.2; standard deviation 11.7). Chronic pain (87.7%), disc displacement (38.2%), and joint inflammation (26.9%) were the most frequently observed signs and symptoms. The genetic polymorphism rs6276 in DRD2 was associated with chronic pain (p=0.033). In conclusion, our study suggests that genetic polymorphisms in DRD2 and ANKK1 may influence TMD signs and symptoms in a group of male construction workers.

Indexed as

Chronic PainConstruction IndustryProtein Serine-Threonine KinasesReceptors, Dopamine D2Temporomandibular Joint DisordersCross-Sectional StudiesGenotypeHumansMaleANKK1 protein, humanDRD2 protein, humanProtein Serine-Threonine KinasesReceptors, Dopamine D2

Identifiers

PMID36043564
PMCPMC9645185
OpenAlexW4293481096

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.