Evidence map›Paper›PMID 36043525›Full record

ArticleInternational journal of oncology2022

Differential dependency of human glioblastoma cells on vascular endothelial growth factor‑A signaling via neuropilin‑1.

Jungwhoi Lee, Kyuha Chong, Jungsul Lee, Chungyeul Kim, Jae-Hoon Kim, Kyungsun Choi, Chulhee Choi

Open access · hybridAbstract read
In one paragraph

Article in International journal of oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jungwhoi Lee *Department of Applied Life Science, Sustainable Agriculture Research Institute (SARI), Jeju National University, Jeju‑do 63243, Republic of Korea.
Kyuha Chong *Department of Neurosurgery, Korea University Guro Hospital, Korea University Medicine, Korea University College of Medicine, Guro‑gu, Seoul 08308, Republic of Korea.
Jungsul LeeDepartment of Bio and Brain Engineering, KAIST, Yuseong‑gu, Daejeon 34141, Republic of Korea.
Chungyeul KimDepartment of Pathology, Korea University Guro Hospital, Korea University Medicine, Korea University College of Medicine, Guro‑gu, Seoul 08308, Republic of Korea.
Jae-Hoon KimDepartment of Applied Life Science, Sustainable Agriculture Research Institute (SARI), Jeju National University, Jeju‑do 63243, Republic of Korea.
Kyungsun ChoiILIAS Biologics Inc., Yuseong‑gu, Daejeon 34014 34014, Republic of Korea.
Chulhee ChoiDepartment of Bio and Brain Engineering, KAIST, Yuseong‑gu, Daejeon 34141, Republic of Korea.
Jeju National University · KRKorea Advanced Institute of Science and Technology · KRKorea University Medical Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the high expression of neuropilin‑1 (NRP‑1) in human glioblastoma (GB), the understanding of its function as a co‑receptor of vascular endothelial growth factor receptors (VEGFRs) in angiogenesis is currently limited. Therefore, the aim of the present study was to elucidate the non‑classical function of NRP‑1 expression in human GB. Expression patterns of NRP‑1 and VEGF‑A were determined by sandwich ELISA, western blot analysis, or immunohistochemistry. Differential dependency of GB cells following ablation of VEGF‑A signaling was validated

Indexed as

GlioblastomaNeuropilin-1Vascular Endothelial Growth Factor AChondroitin SulfatesHumansSignal TransductionChondroitin SulfatesNeuropilin-1NRP1 protein, humanVascular Endothelial Growth Factor AVEGFA protein, humanautocrine signalingchondroitin sulfateFMS related receptor tyrosine kinase 1glioblastomaneuropilin‑1

Identifiers

PMID36043525
PMCPMC9477108
OpenAlexW4293452721

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.