Evidence map›Paper›PMID 36043523›Full record

ArticleMolecular medicine reports2022

CTPS cytoophidia formation affects cell cycle progression and promotes TSN‑induced apoptosis of MKN45 cells.

Xuepeng Fu, Wen Chen, Yang Pan, Chang Liu, Zhenzhu Zhang, Shuli Shao, Weiwei Zhang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Differential Cytoophidium Assembly betweenInternational journal of molecular sciences · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Xuepeng FuDepartment of Life Science and Agroforestry, Qiqihar University, Qiqihar, Heilongjiang 161006, P.R. China.
Wen ChenDepartment of Life Science and Agroforestry, Qiqihar University, Qiqihar, Heilongjiang 161006, P.R. China.
Yang PanDepartment of Life Science and Agroforestry, Qiqihar University, Qiqihar, Heilongjiang 161006, P.R. China.
Chang LiuDepartment of Life Science and Agroforestry, Qiqihar University, Qiqihar, Heilongjiang 161006, P.R. China.
Zhenzhu ZhangDepartment of Life Science and Agroforestry, Qiqihar University, Qiqihar, Heilongjiang 161006, P.R. China.
Shuli ShaoDepartment of Life Science and Agroforestry, Qiqihar University, Qiqihar, Heilongjiang 161006, P.R. China.
Weiwei ZhangDepartment of Life Science and Agroforestry, Qiqihar University, Qiqihar, Heilongjiang 161006, P.R. China.
Qiqihar University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cytidine triphosphate synthase (CTPS) forms filamentous structures termed cytoophidia in numerous types of cell. Toosendanin (TSN) is a tetracyclic triterpenoid and induces CTPS to form cytoophidia in MKN45 cells. However, the effects of CTPS cytoophidia on the proliferation and apoptosis of human gastric cancer cells remain poorly understood. In the present study, CTPS‑overexpression and R294D‑CTPS mutant vectors were generated to assess the effect of CTPS cytoophidia on the proliferation and apoptosis of gastric cancer MKN45 cells. Formation of CTPS cytoophidia significantly inhibited MKN45 cell proliferation (evaluated using EdU incorporation assay), significantly blocked the cell cycle in G

Indexed as

Stomach NeoplasmsApoptosisCell CycleCell Line, TumorCell ProliferationCytidine TriphosphateHumansRNA, MessengerTriterpenesCytidine TriphosphateRNA, MessengertoosendaninTriterpenesapoptosiscell cyclecytidine triphosphate synthasecytoophidiagastric cancertoosendanin

Identifiers

PMID36043523
PMCPMC9471557
OpenAlexW4293426422

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.