Evidence map›Paper›PMID 36043519›Full record

ArticleMolecular medicine reports2022

The epigenetic impact of suberohydroxamic acid and 5‑Aza‑2'‑deoxycytidine on DNMT3B expression in myeloma cell lines differing in IL‑6 expression.

Katerina Smesny Trtkova, Petra Luzna, Denisa Weiser Drozdkova, Katerina Cizkova, Lucie Janovska, Jan Gursky, Dana Prukova, Ivo Frydrych, Marian Hajduch, Jiri Minarik

Open access · hybridAbstract read
In one paragraph

Article in Molecular medicine reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Katerina Smesny TrtkovaDepartment of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 777 15 Olomouc, Czech Republic.
Petra LuznaDepartment of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 777 15 Olomouc, Czech Republic.
Denisa Weiser DrozdkovaDepartment of Clinical and Molecular Pathology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 777 15 Olomouc, Czech Republic.
Katerina CizkovaDepartment of Histology and Embryology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 777 15 Olomouc, Czech Republic.
Lucie JanovskaDepartment of Microbiology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 777 15 Olomouc, Czech Republic.
Jan GurskyDepartment of Biology, Faculty of Medicine and Dentistry, Palacky University Olomouc, 777 15 Olomouc, Czech Republic.
Dana PrukovaInstitute of Pathological Physiology, First Faculty of Medicine, Charles University, 121 08 Prague, Czech Republic.
Ivo FrydrychInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, 779 00 Olomouc, Czech Republic.
Marian HajduchInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, 779 00 Olomouc, Czech Republic.
Jiri MinarikDepartment of Hemato‑Oncology, University Hospital Olomouc, 779 00 Olomouc, Czech Republic.
Palacký University Olomouc · CZCharles University · CZInstitute of Molecular and Translational Medicine · CZUniversity Hospital Olomouc · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gene inactivation of the cyclin‑dependent kinase inhibitors p16

Indexed as

DecitabineDNA (Cytosine-5-)-MethyltransferasesEpigenesis, GeneticMultiple MyelomaCell Cycle ProteinsCell Line, TumorCyclin-Dependent Kinase Inhibitor p15Cyclin-Dependent Kinase Inhibitor p16DNA MethylationDNA Methyltransferase 3BGene SilencingHumansInterleukin-6Tumor Suppressor Protein p53Cell Cycle ProteinsCyclin-Dependent Kinase Inhibitor p15Cyclin-Dependent Kinase Inhibitor p16DecitabineDNA (Cytosine-5-)-MethyltransferasesDNA Methyltransferase 3BInterleukin-6Tumor Suppressor Protein p53cyclin‑dependent kinase inhibitorDNA methylationinterleukin‑6multiple myeloma cell lines

Identifiers

PMID36043519
PMCPMC9471560
OpenAlexW4293759737

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.