Evidence map›Paper›PMID 36043481›Full record

ArticleClinical and translational science2022

An untargeted metabolomics analysis of exogenous chemicals in human milk and transfer to the infant.

Sydney Thomas, Julia M Gauglitz, Anupriya Tripathi, Fernando Vargas, Kerri Bertrand, Jae H Kim, Christina Chambers, Pieter C Dorrestein, Shirley M Tsunoda

Open access · goldAbstract read
In one paragraph

Article in Clinical and translational science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Sydney ThomasSkaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA.ORCID 0000-0001-8261-1195
Julia M GauglitzSkaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA.ORCID 0000-0003-3146-2489
Anupriya TripathiSkaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA.
Fernando VargasSkaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA.ORCID 0000-0001-5847-2439
Kerri BertrandDivision of Dysmorphology and Teratology, Department of Pediatrics, UC San Diego, La Jolla, California, USA.ORCID 0000-0002-0531-598X
Jae H KimDepartment of Pediatrics, Perinatal Institute, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.ORCID 0000-0001-6321-2594
Christina ChambersDivision of Dysmorphology and Teratology, Department of Pediatrics, UC San Diego, La Jolla, California, USA.ORCID 0000-0003-4675-7722
Pieter C DorresteinSkaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA.
Shirley M TsunodaSkaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, California, USA.ORCID 0000-0002-3974-8038
University of California San Diego · USPerinatal Institute · GB

Funding

The impact of ampicillin and breast milk oligosaccharides on the infant microbiome and immune functionsP50HD106463 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Lars Bode, CHRISTINA CHAMBERS · 2021 to 2026
$19.6M
Developing Pediatric Clinical Pharmacologists for the Advancement of TherapeuticsT32HD087978 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI NIZET, VICTOR, TREMOULET, ADRIANA H · 2016 to 2025
$1.5M
NICHD NIH HHS P50 HD106463NICHD NIH HHS P50HD106463NICHD NIH HHS T32HD087978
6 · The paper itself

Abstract

Human milk is the optimal infant nutrition. However, although human-derived metabolites (such as lipids and oligosaccharides) in human milk are regularly reported, the presence of exogenous chemicals (such as drugs, food, and synthetic compounds) are often not addressed. To understand the types of exogenous compounds that might be present, human milk (n = 996) was analyzed by untargeted metabolomics. This analysis revealed that lifestyle molecules, such as medications and their metabolites, and industrial sources, such as plasticizers, cosmetics, and other personal care products, are found in human milk. We provide further evidence that some of these lifestyle molecules are also detectable in the newborn's stool. Thus, this study gives important insight into the types of exposures infants receiving human milk might ingest due to the lifestyle choices, exposure, or medical status of the lactating parent.

Indexed as

LactationMilk, HumanFemaleHumansInfantInfant, NewbornMetabolomics

Identifiers

PMID36043481
PMCPMC9652431
OpenAlexW4293765071

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.