Evidence map›Paper›PMID 36043451›Full record

ArticleESC heart failure2022

Neuroendocrine hormone status and diuretic response to atrial natriuretic peptide in patients with acute heart failure.

Shingo Matsumoto, Norihito Nakamura, Masaaki Konishi, Atsushi Shibata, Keisuke Kida, Shunsuke Ishii, Takanori Ikeda, Yuji Ikari

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Shingo MatsumotoDivision of Cardiovascular Medicine, Department of Internal Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
Norihito NakamuraDepartment of Cardiology, Tokai University Hospital, Isehara, Japan.
Masaaki KonishiDepartment of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
Atsushi ShibataDepartment of Cardiovascular Medicine, Osaka City University Graduate School of Medicine, Osaka, Japan.
Keisuke KidaDepartment of Pharmacology, St. Marianna University School of Medicine, Kawasaki, Japan.
Shunsuke IshiiDepartment of Cardiovascular Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Takanori IkedaDivision of Cardiovascular Medicine, Department of Internal Medicine, Toho University Faculty of Medicine, Tokyo, Japan.
Yuji IkariDepartment of Cardiology, Tokai University Hospital, Isehara, Japan.
Toho University · JPTokai University Hospital · JPKitasato University · JPOsaka City University · JPSt. Marianna University School of Medicine · JPYokohama City University Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsGiven the various effects of sacubitril/valsartan in heart failure, a deeper understanding of atrial natriuretic peptide (ANP) actions is warranted. Natriuresis is a fundamental action of ANP in acute heart failure (AHF), whereas the diuretic effect of ANP is different in each patient according to the diversity of renal response to ANP, which is affected by baseline plasma ANP status and deficiency of circulating ANP. Meanwhile, associations between other neuroendocrine hormones and the diuretic response to ANP are unclear. This study investigated the impact of pivotal neuroendocrine hormones on the diuretic effects of exogenous ANP, carperitide. METHODS AND

resultsPlasma ANP, renin, aldosterone, and vasopressin levels and the diuretic effect of 0.0125 μg/kg/min of carperitide alone for the first 6 h were prospectively evaluated in 75 patients with AHF. Lower ANP levels were significantly associated with a greater diuretic response to exogenous ANP (r = -0.35, P = 0.002). Additionally, higher vasopressin levels were significantly related to the poor diuretic effects of exogenous ANP (r = -0.54, P < 0.001). Plasma ANP and vasopressin concentrations were not significantly correlated (r = 0.19, P = 0.10). Baseline systolic blood pressure, renal function, and prior use of loop diuretics did not predict the diuretic response to exogenous ANP, whereas vasopressin levels independently predicted a diuretic response to exogenous ANP (P < 0.001), as well as lower plasma ANP levels (P = 0.027).

conclusionsVasopressin status was significantly associated with the diuretic response to exogenous ANP in AHF, independent of plasma ANP status. The results may provide a better understanding of the actions of sacubitril/valsartan.

Indexed as

DiureticsHeart FailureAminobutyratesAtrial Natriuretic FactorBiphenyl CompoundsHumansNeurosecretory SystemsValsartanVasopressinsAminobutyratesAtrial Natriuretic FactorBiphenyl CompoundsDiureticssacubitrilValsartanVasopressinsAcute heart failureAtrial natriuretic peptideCarperitidePlasma osmolalityVasopressin

Identifiers

PMID36043451
PMCPMC9773655
OpenAlexW4293741374

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.