ArticleVeterinary dermatology2022
Evaluation of the theoretical risk of cross-reactivity among recently identified food allergens for dogs.
Article in Veterinary dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Molecular Allergen Sensitization Profiling in a Large Cohort of Dogs Suspected of Allergic Diseases in the USA: Prevalence and Unsupervised IgE Clustering (2024-2025).Animals : an open access journal from MDPI · 2026Article
- A prospective double-blinded study evaluating threshold doses of dietary allergens that trigger adverse food reactions in dogs, and time to flare after exposure.Frontiers in veterinary science · 2026Article
- Validation of a Multiplex Molecular Macroarray for the Determination of Allergen-Specific IgE Sensitizations in Dogs.Veterinary sciences · 2024Article
- Analysis of Intestinal Microbiota and Metabolic Pathways before and after a 2-Month-Long Hydrolyzed Fish and Rice Starch Hypoallergenic Diet Trial in Pruritic Dogs.Veterinary sciences · 2023Article
- Evaluation of the theoretical risk of cross-reactivity among recently identified food allergens for dogs.Veterinary dermatology · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThere is increasing evidence of cross-reactivity between allergens of close or distant species. The A-RISC (Allergens'-Relative Identity, Similarity and Cross-reactivity) index helps evaluate the risk of theoretical cross-reactivity between proteins of the same family among different species.
objectivesTo report the A-RISC indices for several food allergens of dogs between multiple food sources. MATERIALS AND
methodsWe selected several recently characterised food allergens for dogs from fish and chicken (ACTA1, ALDOA, CKM, ENO3, GAPDH, PKM and TPI1), fish (TPM1/2), beef/lamb (PGM1) and corn/potato (WAXY). When quality sequence data were available, A-RISC indices were calculated between multiple animal and plant species that can be used as food sources. For the TPM subunits, A-RISC indices also were calculated with the environmental allergens Bla g 4 and Der f 10, and the Toxocara canis nematode.
resultsThe A-RISC indices suggest a substantial theoretical risk of cross-reactivity between species for all allergens considered. For TPM, this risk also extends to the environmental and nematode allergens. CONCLUSIONS AND CLINICAL RELEVANCE: There is a high theoretical risk of cross-reactivity between allergens of different species used as food sources. The clinical relevance of these elevated A-RISC indices should be studied further.
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