Evidence map›Paper›PMID 36043177›Full record

ArticleOpen forum infectious diseases2022

Immunogenicity of a Three-Dose Primary Series of mRNA COVID-19 Vaccines in Patients With Lymphoid Malignancies.

Amy C Sherman, Jennifer L Crombie, ChiAn Cheng, Michaël Desjardins, Guohai Zhou, Omolola Ometoruwa, Rebecca Rooks, Yasmeen Senussi, Mikaela McDonough, Liliana I Guerrero and 9 more

Abstract read
In one paragraph

Article in Open forum infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Protracted SARS-CoV-2 Infection in B-cell Depleted Patients: Immunologic and Viral Characteristics and Response to Dual and Extended Antiviral Therapy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2026
    Article
  4. Article
  5. COVID-19 Vaccine Efficacy in Participants With Weakened Immune Systems From 4 Randomized Controlled Trials.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Amy C ShermanDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-6075-3990
Jennifer L CrombieDana-Farber Cancer Institute, Boston, Massachusetts, USA.
ChiAn ChengHarvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-6657-9137
Michaël DesjardinsDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-4028-8507
Guohai ZhouDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Omolola OmetoruwaDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Rebecca RooksDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Yasmeen SenussiHarvard Medical School, Boston, Massachusetts, USA.
Mikaela McDonoughDana-Farber Cancer Institute, Boston, Massachusetts, USA.
Liliana I GuerreroDana-Farber Cancer Institute, Boston, Massachusetts, USA.
John KupelianDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Simon Doss-GollinPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Kinga K SmolenPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Simon D van HarenPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
Philippe ArmandDana-Farber Cancer Institute, Boston, Massachusetts, USA.
Ofer LevyPrecision Vaccines Program, Division of Infectious Diseases, Boston Children's Hospital, Boston, Massachusetts, USA.
David R WaltHarvard Medical School, Boston, Massachusetts, USA.
Lindsey R BadenDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.
Nicolas C IssaDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, Massachusetts, USA.

Funding

The Harvard Clinical and Translational Science CenterUL1TR002541 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2018 to 2022
$93.0M
NCATS NIH HHS UL1 TR002541
6 · The paper itself

Abstract

Background: Patients with lymphoid malignancies are at risk for poor coronavirus disease 2019 (COVID-19)-related outcomes and have reduced vaccine-induced immune responses. Currently, a 3-dose primary regimen of mRNA vaccines is recommended in the United States for immunocompromised hosts. Methods: A prospective cohort study of healthy adults ( Results: The rate of seroconversion (68.1% vs 100%) and the magnitude of peak anti-S immunoglobulin G (IgG) titer (median anti-S IgG = 32.4, IQR = 0.48-75.0 vs median anti-S IgG = 72.6, IQR 51.1-100.1; Conclusions: A 3-dose primary mRNA series enhanced anti-S IgG responses to titers equivalent to healthy adults in patients with lymphoid malignancies who were seropositive after the first 2 doses and seroconverted 17.1% who were seronegative after the first 2 doses. T-cell responses were present, raising the possibility that the vaccines may confer some cell-based protection even if not measurable by anti-S IgG.

Indexed as

lymphoid malignanciesmRNA vaccinesprimary seriesSARS-CoV-2

Identifiers

PMID36043177
PMCPMC9384786

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.