ArticleBrain communications2022
Deep-learning retinal vessel calibre measurements and risk of cognitive decline and dementia.
Article in Brain communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Look into my eyes: What can eye-based measures tell us about the relationship between physical activity and cognitive performance?Journal of sport and health science · 2023Pooled it
- Tracer Techniques in Ophthalmology: Ocular Applications and Systemic Connections.Diagnostics (Basel, Switzerland) · 2026Review
- Deep learning retinal imaging model identifies poor brain health among older adults without dementia.Cerebral circulation - cognition and behavior · 2026Article
- Comparison of the additive value of blood-based and retinal biomarkers to clinical features in predicting cognitive decline.Communications medicine · 2025Article
- Measures of retinal health successfully capture risk for Alzheimer's disease and related dementias at midlife.Journal of Alzheimer's disease : JAD · 2025Article
- The association of retinal vessel calibre, white matter hyperintensities and cognitive decline in community-dwelling older adults.Age and ageing · 2025Article
- Choroidal and retinal vascular changes in adults with Down syndrome: Insights into the Alzheimer's disease continuum.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- A deep-learning retinal aging biomarker for cognitive decline and incident dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Artificial intelligence-enhanced retinal imaging as a biomarker for systemic diseases.Theranostics · 2025Review
- Retinal thickness predicts the risk of cognitive decline over five years.Alzheimer's research & therapy · 2024Article
- Associations of Circulating Platelet Endothelial Cell Adhesion Molecule-1 Levels With Progression of Cerebral Small-Vessel Disease, Cognitive Decline, and Incident Dementia.Journal of the American Heart Association · 2024Article
- Value proposition of retinal imaging in Alzheimer's disease screening: A review of eight evolving trends.Progress in retinal and eye research · 2024Review
- Mapping Knowledge Landscapes and Emerging Trends in AI for Dementia Biomarkers: Bibliometric and Visualization Analysis.Journal of medical Internet research · 2024Article
- Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024Review
- Prognostic potentials of AI in ophthalmology: systemic disease forecasting via retinal imaging.Eye and vision (London, England) · 2024Review
- Retinal vessel caliber and cognitive performance: the multi-ethnic study of atherosclerosis (MESA).Scientific reports · 2024Article
- Association of fractal dimension and other retinal vascular network parameters with cognitive performance and neuroimaging biomarkers: The Multi-Ethnic Study of Atherosclerosis (MESA).Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Accurate estimation of biological age and its application in disease prediction using a multimodal image Transformer system.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Ocular biomarkers of cognitive decline based on deep-learning retinal vessel segmentation.BMC geriatrics · 2024Article
- The association of global vessel width with cognitive decline and cerebral small vessel disease burden in the KaiLuan study.Quantitative imaging in medicine and surgery · 2024Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have explored the associations of retinal vessel calibre, measured from retinal photographs or fundus images using semi-automated computer programs, with cognitive impairment and dementia, supporting the concept that retinal blood vessels reflect microvascular changes in the brain. Recently, artificial intelligence deep-learning algorithms have been developed for the fully automated assessment of retinal vessel calibres. Therefore, we aimed to determine whether deep-learning-based retinal vessel calibre measurements are predictive of risk of cognitive decline and dementia. We conducted a prospective study recruiting participants from memory clinics at the National University Hospital and St. Luke's Hospital in Singapore; all participants had comprehensive clinical and neuropsychological examinations at baseline and annually for up to 5 years. Fully automated measurements of retinal arteriolar and venular calibres from retinal fundus images were estimated using a deep-learning system. Cox regression models were then used to assess the relationship between baseline retinal vessel calibre and the risk of cognitive decline and developing dementia, adjusting for age, gender, ethnicity, education, cerebrovascular disease status, hypertension, hyperlipidemia, diabetes, and smoking. A total of 491 participants were included in this study, of whom 254 developed cognitive decline over 5 years. In multivariable models, narrower retinal arteriolar calibre (hazard ratio per standard deviation decrease = 1.258,
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.