ArticleNeuropsychiatric disease and treatment2022
Association Plasma Aβ42 Levels with Alzheimer's Disease and Its Influencing Factors in Chinese Elderly Population.
Article in Neuropsychiatric disease and treatment, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 3 citations in OpenAlex.
- Exosomes: emerging biomarkers and therapeutic potential in postoperative delirium and postoperative cognitive dysfunction.Frontiers in cell and developmental biology · 2026Review
- Serum amyloid beta 42 levels correlated with metabolic syndrome and its components.Frontiers in endocrinology · 2024Article
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
Background and Purpose: Intracerebral Aβ protein deposition is an important pathological mechanism of Alzheimer's disease (AD) and is one of the indicators of early diagnosis of AD. However, invasive lumbar puncture and Aβ PET are difficult to perform in primary units, resulting delays in early diagnosis of AD. In recent years, it has been found that plasma Aβ can reflect the pathological state of AD in early stage, but the results are not consistent. The objective of this study was to explore the association between plasma Aβ42 levels and AD cognitive impairment and its influencing factors in Chinese elderly population, so as to provide guidance for the clinical application of plasma Aβ42 as a blood biomarker of AD. Methods: This is a cross-sectional study based on the community population. Plasma samples were collected from 604 healthy controls (HC), 508 mild cognitive impairment (MCI) and 202 dementia with Alzheimer's type (DAT) patients from three cities. We analyzed the correlation between plasma Aβ42 levels and cognitive function and the influence of confounding factors on the relationship between plasma Aβ42 levels and AD. The independent influencing factors of plasma Aβ42 levels were determined by covariance and linear regression analysis. Results: Our results suggest that there is a special linear relationship between plasma Aβ42 and cognitive impairment of AD in Chinese elderly population, with Aβ42 levels slightly decreased in early AD and significantly increased in moderate-to-severe AD ( Conclusion: This indentifies that plasma Aβ42 may be a peripheral biomarker for AD screening in Chinese elderly population, but it is necessary to establish standardized detection methods and establish different demarcation criteria for various influencing factors.
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