Evidence map›Paper›PMID 36042850›Full record

ArticleMaterials today. Bio2022

Programmable molecular circuit discriminates multidrug-resistant bacteria.

Xiaolin Hu, Weichao Qin, Rui Yuan, Liangliang Zhang, Liangting Wang, Ke Ding, Ruining Liu, Wanyun Huang, Hong Zhang, Yang Luo

Abstract read
In one paragraph

Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaolin HuCenter of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, 174 Shazhengjie, Shapingba District, Chongqing, 400044, China.
Weichao QinDepartment of Clinical Laboratory, Jiangjin Hospital, Chongqing University, 725 Jiangzhou Road, Jiangjin District, Chongqing, 402260, China.
Rui YuanCenter of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, 174 Shazhengjie, Shapingba District, Chongqing, 400044, China.
Liangliang ZhangCenter of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, 174 Shazhengjie, Shapingba District, Chongqing, 400044, China.
Liangting WangCenter of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, 174 Shazhengjie, Shapingba District, Chongqing, 400044, China.
Ke DingDepartment of Oncology, Jiangjin Hospital, Chongqing University, 725 Jiangzhou Road, Jiangjin District, Chongqing, 402260, China.
Ruining LiuCenter of Smart Laboratory and Molecular Medicine, School of Medicine, Chongqing University, 174 Shazhengjie, Shapingba District, Chongqing, 400044, China.
Wanyun HuangLife Science Laboratories, Biology Department, University of Massachusetts Amherst, 240 Thatcher Road, Amherst, MA, 01002, USA.
Hong ZhangDepartment of Clinical Laboratory, The Second Hospital of Shandong University, 247 Beiyuan Street, Jinan, Shandong, 250033, China.
Yang LuoDepartment of Clinical Laboratory, Jiangjin Hospital, Chongqing University, 725 Jiangzhou Road, Jiangjin District, Chongqing, 402260, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recognizing multidrug-resistant (MDR) bacteria with high accuracy and precision from clinical samples has long been a difficulty. For reliable detection of MDR bacteria, we investigated a programmable molecular circuit called the Background-free isothermal circuital kit (BRICK). The BRICK method provides a near-zero background signal by integrating four inherent modules equivalent to the conversion, amplification, separation, and reading modules. Interference elimination is largely owing to a molybdenum disulfide nanosheets-based fluorescence nanoswitch and non-specific suppression mediated by molecular inhibitors. In less than 70 ​min, an accurate distinction of various MDR bacteria was achieved without bacterial lysis. The BRICK technique detected 6.73 ​CFU/mL of methicillin-resistant

Indexed as

AptamerBacteriaDetectionEnzymeInfectionNanomaterials

Identifiers

PMID36042850
PMCPMC9420371

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.