Evidence map›Paper›PMID 36042776›Full record

ArticleCurrent research in immunology2022

Rapid peptide exchange on MHC class I by small molecules elucidates dynamics of bound peptide.

Andries Hadeler, Ankur Saikia, Martin Zacharias, Sebastian Springer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current research in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Empty MHC Class I Protein Production.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Andries HadelerSchool of Science, Jacobs University Bremen, 28759, Bremen, Germany.
Ankur SaikiaSchool of Science, Jacobs University Bremen, 28759, Bremen, Germany.
Martin ZachariasPhysics Department T38, Technical University Munich, 85748 Garching, Germany.
Sebastian SpringerSchool of Science, Jacobs University Bremen, 28759, Bremen, Germany.
Constructor University · DETechnical University of Munich · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complexes of peptides with recombinant major histocompatibility complex class I molecules (rpMHCs) are an important tool for T cell detection, isolation, and activation in cancer immunotherapy. The rapid preparation of rpMHCs is aided by peptide exchange, for which several technologies exist. Here, we show peptide exchange with small-molecule alcohols and demonstrate that they accelerate the dissociation of pre-bound peptides, creating a novel method for rapid production of rpMHCs and increasing the understanding of the conformational flexibility of the MHC-bound peptides.

Indexed as

Fluorescence anisotropyMajor histocompatibility complexMHC class INanoscale differential scanning fluorimetryPeptide exchangeSmall molecule

Identifiers

PMID36042776
PMCPMC9420430
OpenAlexW4293107803

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.