Evidence map›Paper›PMID 36042474›Full record

ArticleItalian journal of pediatrics2022

Cyclic vomiting syndrome in children: a nationwide survey of current practice on behalf of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) and Italian Society of Pediatric Neurology (SINP).

Sara Isoldi, Giovanni Di Nardo, Saverio Mallardo, Pasquale Parisi, Umberto Raucci, Renato Tambucci, Paolo Quitadamo, Silvia Salvatore, Enrico Felici, Fabio Cisarò and 45 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Italian journal of pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Guideline
  2. Clinical features, response to therapy and outcome in pediatric cyclical vomiting syndrome: Experience from the developing world.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

55 authors at 20 institutions in 2 countries.

Sara Isoldi *Maternal and Child Health Department, Santa Maria Goretti Hospital, Sapienza-University of Rome, Latina, Italy.
Giovanni Di Nardo *Department of Neuroscience, Mental Health and Sense Organs (NESMOS), Faculty of Medicine & Psychology, Sant'Andrea Hospital, Sapienza University of Rome, 00189, Rome, Lazio, Italy.
Saverio MallardoMaternal and Child Health Department, Santa Maria Goretti Hospital, Sapienza-University of Rome, Latina, Italy.
Pasquale ParisiDepartment of Neuroscience, Mental Health and Sense Organs (NESMOS), Faculty of Medicine & Psychology, Sant'Andrea Hospital, Sapienza University of Rome, 00189, Rome, Lazio, Italy. pasquale.parisi@uniroma1.it.ORCID http://orcid.org/0000-0001-9042-8120
Umberto RaucciPediatric Emergency Department, Bambino Gesù Children's Hospital, Institute for Research, Hospitalization and Health Care (IRCCS), Rome, Italy.
Renato TambucciDigestive Endoscopy and Surgery Unit, Bambino Gesù Children's Hospital, Institute for Research, Hospitalization and Health Care (IRCCS), Rome, Italy.
Paolo QuitadamoDepartment of Pediatrics, A.O.R.N. Santobono-Pausilipon, Naples, Italy.
Silvia SalvatorePediatric Department, Ospedale "F. Del Ponte", University of Insubria, Varese, Italy.
Enrico FeliciUnit of Pediatrics, The Children Hospital, Azienda Ospedaliera SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
Fabio CisaròPediatric Gastroenterology Unit, Regina Margherita Children's Hospital, Azienda Ospedaliera-Universitaria, Città della Salute e della Scienza di Torino, Turin, Italy.
Licia PensabenePediatric Unit, Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy.
Claudia BanzatoDepartment of Surgical Sciences, Dentistry, Gynecology and Pediatrics, Pediatric Division, University of Verona, Verona, Italy.
Caterina StrisciuglioDepartment of Woman, Child, General and Specialistic Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
Claudio RomanoPediatric Gastroenterology Unit, Department of Human Pathology in Adulthood and Childhood "G. Barresi", University of Messina, Messina, Italy.
Patrizia FuscoPediatric Unit, Montis Regalis Hospital, Mondovì, Cuneo, Italy.
Francesca RigottiDepartment of Pediatrics, Bolzano Hospital, Bolzano, Italy.
Naire SansottaPaediatric Hepatology, Gastroenterology and Transplantation, Hospital Papa Giovanni XXIII, Bergamo, Italy.
Silvia CaimmiPediatric Clinic, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Salvatore SavastaPediatric Clinic, Foundation IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Giovanna ZuinPediatric Department, University of Milano Bicocca, FMBBM, San Gerardo Hospital, Monza, Italy.
Marina Di StefanoDepartment of Pediatrics, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Silvia ProveraDepartment of Pediatrics, IRCCS Sacro Cuore Don Calabria Hospital, Negrar, Verona, Italy.
Angelo CampanozziDepartment of Medical and Surgical Sciences, Pediatric Unit, University of Foggia, Foggia, Italy.
Paolo RossiDepartment of Pediatrics, Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy.
Simona GattiDepartment of Pediatrics, Università Politecnica delle Marche, Ancona, Italy.
Mara CorpinoGastroenterologia Pediatrica, Clinica Pediatrica e Malattie Rare, Ospedale Pediatrico Microcitemico A. Cao, ARNAS Brotzu, Cagliari, Italy.
Patrizia AlvisiDepartment of Paediatrics, Ospedale Maggiore, Azienda USL, Bologna, Italy.
Stefano MartelossiPediatric Unit, Ca' Foncello's Hospital, Treviso, Italy.
Agnese SuppiejPediatric Section, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Paolo GandulliaUOC Gastroenterologia, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Alberto VerrottiDepartment of Pediatrics, University of Perugia, Perugia, Italy.
Gianluca TerrinDepartment of Maternal and Child Health, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Caterina PacenzaDepartment of Pediatrics, San Giovanni di Dio Hospital, Crotone, Italy.
Fabiola FornaroliGastroenterology and Endoscopy Unit, Department of Medicine and Surgery, University of Parma, Parma, Italy.
Donatella ComitoOspedale Santa Croce, Moncalieri, Italy.
Stefano D'ArrigoDevelopmental Neurology Division, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Pasquale StrianoPediatric Neurology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy.
Federico RaviglioneHospital Neuropsychiatry Service, ASST Rhodense, Rho, Milan, Italy.
Marco CarotenutoClinic of Child and Adolescent Neuropsychiatry, Department of Mental Health and Physical and Preventive Medicine, Università degli Studi della Campania "Luigi Vanvitelli", Caserta, Italy.
Alessandro OrsiniPaediatric Neurology Section, Paediatric Department, Pisa University Hospital, University of Pisa, Pisa, Italy.
Vincenzo BelcastroNeurology Unit, Maggiore Hospital, Lodi, Italy.
Giovanna Di CorciaPediatric Department, "Augusto Murri" Hospital, Fermo, Italy.
Vincenzo RaieliChild Neuropsychiatry Unit - ISMEP- ARNAS CIVICO, Palermo, Italy.
Michela Ada Noris FerilliDepartment of Neuroscience, Paediatric Headache Center, Bambino Gesù Children Hospital, IRCCS, Rome, Italy.
Claudia RuscittoChild Neurology and Psychiatry Unit, Systems Medicine Department, Tor Vergata University Hospital of Rome, Rome, Italy.
Elisabetta SpadoniPediatric Department, Azienda Ospedaliera Nord-Ovest of Tuscany, San Luca Hospital of Lucca, Lucca, Italy.
Salvatore GrossoMolecular Medicine and Development, University of Siena, Siena, Italy.
Renato D'AlonzoPediatric and Neonatological Unit, Maternal and Child Department, Nuovo Ospedale San Giovanni Battista, Foligno, Italy.
Amanda PapaInfantile Neuropsychiatry Departement Maggiore della Carità University Hospital, Novara, Italy.
Piero PavoneSection of Pediatrics and Child Neuropsychiatry, Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Mariaclaudia MeliAzienda Policlinico, "Rodolico-San Marco Hospital", University of Catania, Catania, Italy.
Mario VelarditaDepartment of Pediatrics, Hospital "Salvatore e Saverio Gravina", Caltagirone, Italy.
Martina MainettiDepartment of Pediatrics, Santa Maria delle Croci Hospital, Ravenna, Italy.
Nicola VanacoreNational Centre for Epidemiology, Surveillance and Health Promotion, National Institute of Health, Rome, Italy.
Osvaldo BorrelliDivision of Neurogastroenterology and Motility, Department of Pediatric Gastroenterology, University College London (UCL) Institute of Child Health and Great Ormond Street Hospital, London, UK.
Bambino Gesù Children's Hospital · ITAzienda Ospedaliera Sant'Andrea · ITIstituto Giannina Gaslini · ITOspedale Santa Maria Goretti · ITUniversity of Campania "Luigi Vanvitelli" · ITUniversity of Catania · ITUniversity of Pavia · ITAzienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITAzienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo · ITAzienda Ospedaliero Universitaria San Giovanni Battista · ITAziende Socio Sanitaria Territoriale RhodenseCa' Foncello Hospital · ITFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITFondazione IRCCS Istituto Neurologico Carlo Besta · ITGreat Ormond Street Hospital · GBIMT School for Advanced Studies Lucca · ITMagna Graecia University · ITMarche Polytechnic University · ITNuovo Ospedale San Giovanni di Dio · ITOspedale di Bolzano · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCyclic Vomiting Syndrome (CVS) is a rare functional gastrointestinal disorder, which has a considerable burden on quality of life of both children and their family. Aim of the study was to evaluate the diagnostic modalities and therapeutic approach to CVS among Italian tertiary care centers and the differences according to subspecialties, as well as to explore whether potential predictive factors associated with either a poor outcome or a response to a specific treatment.

methodsCross-sectional multicenter web-based survey involving members of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP) and Italian Society of Pediatric Neurology (SINP).

resultsA total of 67 responses were received and analyzed. Most of the respondent units cared for less than 20 patients. More than half of the patients were referred after 3 to 5 episodes, and a quarter after 5 attacks. We report different diagnostic approaches among Italian clinicians, which was particularly evident when comparing gastroenterologists and neurologists. Moreover, our survey demonstrated a predilection of certain drugs during emetic phase according to specific clinic, which reflects the cultural background of physicians.

conclusionIn conclusion, our survey highlights poor consensus amongst clinicians in our country in the diagnosis and the management of children with CVS, raising the need for a national consensus guideline in order to standardize the practice.

Indexed as

Child Nutrition SciencesGastroenterologyHealth Care SurveysNeurologyPediatricsSocieties, MedicalVomitingChildCross-Sectional StudiesHumansItalyPractice Guidelines as TopicTreatment OutcomeCyclic vomitingManagementOutcomesPediatric

Identifiers

PMID36042474
PMCPMC9429644
OpenAlexW4293568932

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.