Evidence map›Paper›PMID 36042436›Full record

Trial reportBMC musculoskeletal disorders2022

The effect of pre-operative carbohydrate loading in femur fracture: a randomized controlled trial.

Narendra Kumar Chaudhary, Dev Ram Sunuwar, Rachit Sharma, Mandeep Karki, Mukti Nath Timilsena, Anita Gurung, Sunil Badgami, Devendra Raj Singh, Prabesh Karki, Kailash Kumar Bhandari and 1 more

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 5 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04838366 nacompletednot on this map

The Effect of Pre-operative Carbohydrate Loading in Femur Fracture: A Randomized Controlled Trial

TypeinterventionalSponsorArmed Police Force Hospital, NepalRan2021 to 2021Enrolled66ConditionsFemur FractureArmsCarbohydrate loading
NCT05823649 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effect of Early Versus Delayed Postoperative Feeding in Lower Limb Fracture Surgery: a Randomized Controlled Trial

TypeinterventionalSponsorArmed Police Force Hospital, NepalRan2023 to 2024Enrolled275ConditionsLower Limb FractureArmsEarly feeding/intervention group
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 5 syntheses or guidelines pooled it, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Narendra Kumar Chaudhary *Nepal Orthopaedic Hospital, Kathmandu, Nepal. mscnarendra2019@gmail.com.ORCID http://orcid.org/0000-0002-7747-4066
Dev Ram Sunuwar *Department of Nutrition and Dietetics, Armed Police Force Hospital, Kathmandu, Nepal.ORCID http://orcid.org/0000-0002-2544-8296
Rachit SharmaNepal Orthopaedic Hospital, Kathmandu, Nepal.
Mandeep KarkiNepal Orthopaedic Hospital, Kathmandu, Nepal.
Mukti Nath TimilsenaNepal Orthopaedic Hospital, Kathmandu, Nepal.
Anita GurungNepal Orthopaedic Hospital, Kathmandu, Nepal.
Sunil BadgamiNepal Orthopaedic Hospital, Kathmandu, Nepal.
Devendra Raj SinghSchool of Human and Health Sciences, University of Huddersfield, Huddersfield, UK.ORCID http://orcid.org/0000-0003-1450-9476
Prabesh KarkiGreentara College of Health Sciences, Lalitpur, Nepal.
Kailash Kumar BhandariNepal Orthopaedic Hospital, Kathmandu, Nepal.ORCID http://orcid.org/0000-0001-6971-9732
Pranil Man Singh PradhanDepartment of Community Medicine and Public Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal.ORCID http://orcid.org/0000-0002-0066-8583
Nepal Orthopaedic HospitalCivil Service Hospital · NPTribhuvan University · NPUniversity of Huddersfield · GB

Funding

Nepal Health Research Council (NHRC) Grant number: 110/2021
6 · The paper itself

Abstract

backgroundFemur fracture is a major burden among elderly people, leading patients to be bedridden for a long time in the hospital. The body is more likely to be in a catabolic state as a result of the prolonged fasting period required for surgery, leading to an increase in insulin resistance. Pre-operative carbohydrate loading has been shown to improve postoperative outcomes in several countries. The study aimed to evaluate the effect of pre-operative carbohydrate loading in femur fracture surgery.

methodsThis study was single-center, hospital-based, open-label, parallel-group randomized controlled trial conducted between August 2020 and November 2021. A total of 66 participants, aged 50 years and above having femur fractures planned for surgery were included in this study and assigned to the control (n = 33) and study (n = 33) groups through computer-generated random numbers. The control group was kept fasting from midnight to the next morning as in existence while the study group was intervened with carbohydrate loading according to the Enhanced Recovery After Surgery (ERAS) protocol. The pre-operative nutritional status was identified and the postoperative outcomes were measured using the Visual Analogue Score (VAS), Cumulative Ambulatory Score (CAS), and Modified Barthel Index (MBI) scoring systems. Statistical analyses were performed using the Chi-square test and the Student's two-sample t-test to compare the outcomes between the two groups.

resultsAll the participants completed the study. There was a significant reduction in the average postoperative pain in the carbohydrate loading group (VAS: 4.8 (SD ± 1.8), 95% CI: 4.7-5.4) as compared to the control group (VAS: 6.1 (SD ± 2.1), 95% CI: 5.3-6.8). The average CAS showed a significant improvement in regaining the mobility function of participants in the study group (CAS: 8.1 (SD ± 2.8), 95% CI: 7.1-9.1) than that of the control group (CAS: 6.8 (SD ± 2.8), 95% CI: 5.8-7.8). The mean MBI score of the participants at the time of discharge from the hospital was higher in the study group (MBI:13.1 (SD ± 2.3), 95% CI: 12.2-13.9) compared to the control group (MBI: 11.8 (SD ± 3.1), 95% CI:10.6-12.9). Similarly, the length of hospital stay after surgery had decreased in the study group than in the control group.

conclusionsThe uptake of carbohydrate loading showed reduced post-operative pain, enhanced functional mobility, and decreased length of hospital stay. This study warrants larger trials to show the effect of pre-operative carbohydrate loading in a clinical setting.

trial registrationNCT04838366, first registered on 09/042021 ( https://clinicaltrials.gov/ct2/show/NCT04838366 ).

Indexed as

Diet, Carbohydrate LoadingFemoral FracturesAgedFemurHumansLength of StayPostoperative PainPreoperative CareFemur fractureNepalPre-operative carbohydrate loadingSurgery

Identifiers

PMID36042436
PMCPMC9424836
OpenAlexW4293536196

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.