Evidence map›Paper›PMID 36042372›Full record

ArticleScientific reports2022

Decreased NHE3 expression in colon cancer is associated with DNA damage, increased inflammation and tumor growth.

Daniel Laubitz, Michael A Gurney, Monica Midura-Kiela, Christy Clutter, David G Besselsen, Hao Chen, Fayez K Ghishan, Pawel R Kiela

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. New functions and roles of the NaPflugers Archiv : European journal of physiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Daniel Laubitz *Department of Pediatrics, Steele Children's Research Center, University of Arizona College of Medicine, 1501 N. Campbell Ave, Tucson, AZ, 85724, USA.
Michael A Gurney *Department of Pediatrics, Steele Children's Research Center, University of Arizona College of Medicine, 1501 N. Campbell Ave, Tucson, AZ, 85724, USA.
Monica Midura-KielaDepartment of Pediatrics, Steele Children's Research Center, University of Arizona College of Medicine, 1501 N. Campbell Ave, Tucson, AZ, 85724, USA.
Christy ClutterDepartment of Pediatrics, Steele Children's Research Center, University of Arizona College of Medicine, 1501 N. Campbell Ave, Tucson, AZ, 85724, USA.
David G BesselsenUniversity Animal Care, University of Arizona, Tucson, AZ, USA.
Hao ChenDepartment of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Fayez K GhishanDepartment of Pediatrics, Steele Children's Research Center, University of Arizona College of Medicine, 1501 N. Campbell Ave, Tucson, AZ, 85724, USA.
Pawel R KielaDepartment of Pediatrics, Steele Children's Research Center, University of Arizona College of Medicine, 1501 N. Campbell Ave, Tucson, AZ, 85724, USA. pkiela@peds.arizona.edu.
University of Arizona · USThe University of Texas Southwestern Medical Center · US

Funding

DEVELOPMENT OF INTESTINAL ION TRANSPORTR01DK041274 · NIDDK · VANDERBILT UNIVERSITY · PI GHISHAN, FAYEZ KHALAF, KIELA, PAWEL R · 1988 to 2016
$5.5M
Research Supplements to Promote Diversity in Health-Related ResearchR01DK119198 · NIDDK · RUTGERS THE STATE UNIV OF NJ NEWARK · PI GAO, NAN, KIELA, PAWEL R · 2019 to 2023
$1.9M
Novel Roles of Sodium Hydrogen Exchanger 8 (NHE8) in Mucosal HomeostasisR01DK113754 · NIDDK · UNIVERSITY OF ARIZONA · PI GHISHAN, FAYEZ KHALAF · 2017 to 2020
$1.4M
NIDDK NIH HHS R01 DK041274NIDDK NIH HHS R01 DK113754NIDDK NIH HHS R01 DK119198NIH HHS 5R01DK113754
6 · The paper itself

Abstract

Dysregulation of intra- and extracellular pH in cancer contributes to extracellular matrix remodeling, favors cell migration, proliferation, and metastasis. Although the primary attention has been focused on the role of the ubiquitous Na

Indexed as

Colonic NeoplasmsSodium-Hydrogen ExchangersAnimalsDNA DamageInflammationMiceProtein IsoformsSodium-Hydrogen Exchanger 3Protein IsoformsSlc9a3 protein, mouseSodium-Hydrogen Exchanger 3Sodium-Hydrogen Exchangers

Identifiers

PMID36042372
PMCPMC9427942
OpenAlexW4293576835

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.