ArticlePediatric research2023
Outcomes of Babies with Opioid Exposure (OBOE): protocol of a prospective longitudinal cohort study.
Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 22 citations in OpenAlex.
- Limbic System Microstructure in Neonates With Antenatal Opioid Exposure.JAMA network open · 2026Article
- Antenatal Opioid Exposure and Cerebral Cortical Maturation in Newborns.JAMA network open · 2026Article
- Disrupted Brain Connectivity in Newborns Following Antenatal Opioid Exposure.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Observational
- Tobacco and cannabis use among pregnant women with prenatal opioid use.Addictive behaviors · 2025Article
- Prenatal Opioid Exposure Is Associated with Punctate White Matter Lesions in Term Newborns.The Journal of pediatrics · 2025Observational
- Neurobehavioral Profiles in Opioid-Exposed and Unexposed Neonates.The Journal of pediatrics · 2025Observational
- Risk factors for food insecurity and association with prenatal care utilization among women who took opioids during pregnancy and unexposed controls.BMC pregnancy and childbirth · 2025Observational
- Supplementing Consent for a Prospective Longitudinal Cohort Study of Infants With Antenatal Opioid Exposure: Development and Assessment of a Digital Tool.JMIR formative research · 2025Observational
- Understanding vision outcomes in children with history of prenatal opioid exposure: a single-center pilot study.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Motion Robust MR Fingerprinting Scan to Image Neonates With Prenatal Opioid Exposure.Journal of magnetic resonance imaging : JMRI · 2024Article
- Psychological distress among postpartum women who took opioids during pregnancy: the role of perceived stigma in healthcare settings.Archives of women's mental health · 2024Article
- Advances in the Care of Infants With Prenatal Opioid Exposure and Neonatal Opioid Withdrawal Syndrome.Pediatrics · 2024Review
- Impaired vision in children prenatally exposed to methadone: an observational cohort study.Eye (London, England) · 2024Observational
- Rapid anatomical imaging of the neonatal brain using TMagnetic resonance in medicine · 2023Article
- Psychometric Properties of the Prenatal Opioid Use Perceived Stigma Scale and Its Use in Prenatal Care.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2023Article
- Executive functioning, behavioural, emotional, and cognitive difficulties in school-aged children prenatally exposed to methadone.Frontiers in pediatrics · 2023Article
- The immediate and long-term effects of prenatal opioid exposure.Frontiers in pediatrics · 2022Review
- Lessons Learned in Virtual Launch of an Antenatal Opioid Exposure Study During the COVID-19 Pandemic.Nursing researchObservational
- Trends in maternal opioid use: Statewide differences by sociodemographic characteristics in Florida from 2000 to 2019.Journal of addictive diseasesArticle
Corrections and comments
- Erratum issued
Authors and funding
14 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundWhile the health, social, and economic impacts of opioid addiction on adults and their communities are well known, the impact of maternal opioid use on the fetus exposed in utero is less well understood.
methodsThis paper presents the protocol of the ACT NOW Outcomes of Babies with Opioid Exposure (OBOE) Study, a multi-site prospective longitudinal cohort study of infants with antenatal opioid exposure and unexposed controls. Study objectives are to determine the impact of antenatal opioid exposure on brain development and neurodevelopmental outcomes over the first 2 years of life and explore whether family, home, and community factors modify developmental trajectories during this critical time period.
resultsPrimary outcomes related to brain development include cortical volumes, deep cerebral gray matter volumes, resting-state functional connectivity measures, and structural connectivity measures using diffusion tensor imaging. Primary neurodevelopmental outcomes include visual abnormalities, cognitive, language, and motor skills measured using the Bayley Scales of Infant Development and social-emotional and behavioral problems and competence measured by the Brief Infant-Toddler Social and Emotional Assessment.
conclusionsThe OBOE study has been designed to overcome challenges of previous studies and will help further understanding of the effects of antenatal opioid exposure on early infant development. IMPACT: This study will integrate MRI findings and comprehensive neurodevelopmental assessments to provide early insights into the functional topography of the brain in this high-risk population and assess MRI as a potential biomarker. Rather than conducting neuroimaging at a single time point, the study will include serial MRI assessments from birth to 2 years, allowing for the examination of trajectories throughout this period of rapid brain development. While previous studies often have had limited information on exposures, this study will use umbilical cord assays to accurately measure amounts of opioids and other substances from 20 weeks of gestation to birth.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.