ArticleNature neuroscience2022
A molecularly integrated amygdalo-fronto-striatal network coordinates flexible learning and memory.
Article in Nature neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Neuromodulators of orbitofrontal cortex function: A review of endocannabinoid, neurotrophin, and cell adhesion systems.Neurobiology of disease · 2026Review
- Social rank modulates empathic pain via Galntl6Molecular psychiatry · 2026Article
- Topographic Mesocortex-Amygdalar Projections Expand the Molecular and Functional Model of the Limbic System.Molecular neurobiology · 2026Article
- Cognitive training shapes brain plasticity and schematic representations.Behavioral and brain functions : BBF · 2025Review
- Lower reward sensitivity in frontostriatal stroke: Influence of depression and resting-state functional connectivity.Cognitive, affective & behavioral neuroscience · 2025Article
- Parallel neuronal structural plasticity with memory trace formation in the orbitofrontal cortex.Nature communications · 2025Article
- Action inflexibility and compulsive-like behavior accompany neurobiological alterations in the anterior orbitofrontal cortex and associated striatal nuclei.Scientific reports · 2025Article
- Article
- Social experience in adolescence shapes prefrontal cortex structure and function in adulthood.Molecular psychiatry · 2024Article
- Dorsomedial Striatum CB1R signaling is required for Pavlovian outcome devaluation in male Long Evans rats and reduces inhibitory synaptic transmission in both sexes.bioRxiv : the preprint server for biology · 2024Article
- Article
- A molecularly defined orbitofrontal cortical neuron population controls compulsive-like behavior, but not inflexible choice or habit.Progress in neurobiology · 2024Article
- Control of goal-directed and inflexible actions by dorsal striatal melanocortin systems, in coordination with the central nucleus of the amygdala.Progress in neurobiology · 2024Article
- Functional specialization of medial and lateral orbitofrontal cortex in inferential decision-making.iScience · 2024Article
- Neuronal Ensembles in the Amygdala Allow Social Information to Motivate Later Decisions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Training-induced circuit-specific excitatory synaptogenesis in mice is required for effort control.Nature communications · 2023Article
- Subunit-selective PI3-kinase control of action strategies in the medial prefrontal cortex.Neurobiology of learning and memory · 2023Article
- Orbitofrontal cortex control of striatum leads economic decision-making.Nature neuroscience · 2023Article
- Medial orbitofrontal neurotrophin systems integrate hippocampal input into outcome-specific value representations.Cell reports · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Behavioral flexibility-that is, the ability to deviate from established behavioral sequences-is critical for navigating dynamic environments and requires the durable encoding and retrieval of new memories to guide future choice. The orbitofrontal cortex (OFC) supports outcome-guided behaviors. However, the coordinated neural circuitry and cellular mechanisms by which OFC connections sustain flexible learning and memory remain elusive. Here we demonstrate in mice that basolateral amygdala (BLA)→OFC projections bidirectionally control memory formation when familiar behaviors are unexpectedly not rewarded, whereas OFC→dorsomedial striatum (DMS) projections facilitate memory retrieval. OFC neuronal ensembles store a memory trace for newly learned information, which appears to be facilitated by circuit-specific dendritic spine plasticity and neurotrophin signaling within defined BLA-OFC-DMS connections and obstructed by cocaine. Thus, we describe the directional transmission of information within an integrated amygdalo-fronto-striatal circuit across time, whereby novel memories are encoded by BLA→OFC inputs, represented within OFC ensembles and retrieved via OFC→DMS outputs during future choice.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.